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Probiotic Kefir Improves Renal Disorders in Ovariectomized Female SHR with High Fructose Intake–Induced Metabolic Syndrome

2025-03Artigo científico Acesso aberto
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dc.contributor.authorda Silva Escouto, Leonardo
dc.contributor.authorBatista, Thatiany Jardim
dc.contributor.authorPeixoto, Pollyana
dc.contributor.authorFirmino, Felipe Tonon
dc.contributor.authorRonchi, Silas Nascimento
dc.contributor.authorde Souza Barroso, Maria Eduarda
dc.contributor.authorKampke, Edgar Hell
dc.contributor.authorde Andrade, Tadeu Uggere
dc.contributor.authorde Melo Junior, Antonio Ferreira
dc.contributor.authorBissoli, Nazaré Souza
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutioniNOVA4Health - pólo NMS
dc.contributor.pblSpringer
dc.date.accessioned2025-04-10T15:58:47Z
dc.date.available2025-04-10T15:58:47Z
dc.date.issued2025-03
dc.descriptionFunding Information: Open access funding provided by FCT|FCCN (b-on). This project was supported by the Funda\u00E7\u00E3o de Amparo \u00E0 Pesquisa e Inova\u00E7\u00E3o do Esp\u00EDrito Santo (Fapes): Grants 23/2018 (591/2018) and 15/2022 (687/2022). L.S.E. was a recipient of Fapes Foundation Scholarship. Conselho Nacional de Desenvolvimento Cient\u00EDfico e Tecnol\u00F3gico (CNPq), Brazil. Publisher Copyright: © The Author(s) 2025.
dc.description.abstractWomen in postmenopausal period may present several comorbidities linked to metabolic syndrome (MetS). Our hypothesis is that kefir may prevent the deleterious effects in renal function in an experimental model of metabolic syndrome (MetS) and ovarian hormone deficiency. Young female spontaneously hypertensive rats (SHR) were divided into four groups: ovariectomized (OVX) control, OVX fructose, OVX kefir, and OVX kefir + fructose. They received kefir (5% w/v) via gavage for 8 weeks, while fructose (10% w/v) was available ad libitum. In ponderal parameters and glucose metabolism, we observe that fructose-overloaded groups (OF and OKF) showed increased weight, visceral fat, and fasting blood glucose. However, OKF partially reduced glycemic peak in the glucose tolerance test. Moreover, the standard method for the measurement of renal function showed that OF and OKF groups had a reduction in glomerular filtration rate, and surprisingly OKF exhibited increased renal flow (RBF and RPF) and decreased resistance (RVR). These might be associated with the findings in oxidative stress and nitric oxide (NO) bioavailability, in which kefir in the OKF group was capable of increasing total nitrogen oxides (NOx), attenuate the generation of hydrogen peroxide (DCF) and peroxynitrite (HPF), and also decreased the elevated microalbuminuria promoted by fructose even though the systemic blood pressure between the groups did not differ. Taking together our results, in the present study, kefir showed favorable effects in the model of metabolic syndrome and ovarian hormone deficiency (OKF), potentially protecting the kidney from the deleterious effects of fructose.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2122375
dc.identifier.doi10.1007/s12602-025-10490-w
dc.identifier.issn1867-1306
dc.identifier.otherPURE: 114067376
dc.identifier.otherPURE UUID: ba6665b1-4b5a-4c75-ad0a-93f83cdd0c55
dc.identifier.otherScopus: 105000037825
dc.identifier.urihttp://hdl.handle.net/10362/182053
dc.identifier.urlhttps://www.scopus.com/pages/publications/105000037825
dc.language.isoeng
dc.peerreviewedyes
dc.subjectFemale SHR
dc.subjectKefir
dc.subjectMetabolic syndrome
dc.subjectOxidative stress
dc.subjectRenal function
dc.subjectMicrobiology
dc.subjectMolecular Medicine
dc.subjectMolecular Biology
dc.titleProbiotic Kefir Improves Renal Disorders in Ovariectomized Female SHR with High Fructose Intake–Induced Metabolic Syndromeen
dc.typejournal article
degois.publication.titleProbiotics and Antimicrobial Proteins
dspace.entity.typePublication
rcaap.rightsopenAccess

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