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SARS-CoV-2 vaccine safety in adolescents with inflammatory rheumatic and musculoskeletal diseases and adults with juvenile idiopathic arthritis

2022-07-01Artigo científico Acesso aberto
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dc.contributor.authorLawson-Tovey, Saskia
dc.contributor.authorMachado, Pedro M.
dc.contributor.authorStrangfeld, Anja
dc.contributor.authorMateus, Elsa
dc.contributor.authorGossec, Laure
dc.contributor.authorCarmona, Loreto
dc.contributor.authorRaffeiner, Bernd
dc.contributor.authorBulina, Inita
dc.contributor.authorClemente, Daniel
dc.contributor.authorZepa, Julija
dc.contributor.authorRodrigues, Ana M.
dc.contributor.authorMariette, Xavier
dc.contributor.authorHyrich, Kimme L.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblBMJ Publishing Group
dc.date.accessioned2022-09-08T22:49:04Z
dc.date.available2022-09-08T22:49:04Z
dc.date.issued2022-07-01
dc.descriptionPublisher Copyright: © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
dc.description.abstractBACKGROUND: There is a lack of data on SARS-CoV-2 vaccination safety in children and young people (CYP) with rheumatic and musculoskeletal diseases (RMDs). Current vaccination guidance is based on data from adults with RMDs or CYP without RMDs. OBJECTIVES: To describe the safety of SARS-COV-2 vaccination in adolescents with inflammatory RMDs and adults with juvenile idiopathic arthritis (JIA). METHODS: We described patient characteristics, flares and adverse events (AEs) in adolescent cases under 18 with inflammatory RMDs and adult cases aged 18 or above with JIA submitted to the European Alliance of Associations for Rheumatology COVAX registry. RESULTS: A total of 110 cases were reported to the registry. Thirty-six adolescent cases were reported from four countries, most with JIA (42%). Over half (56%) reported early reactogenic-like AEs. One mild polyarthralgia flare and one serious AE of special interest (malaise) were reported. No CYP reported SARS-CoV-2 infection postvaccination.Seventy-four adult JIA cases were reported from 11 countries. Almost two-thirds (62%) reported early reactogenic-like AEs and two flares were reported (mild polyarthralgia and moderate uveitis). No serious AEs of special interest were reported among adults with JIA. Three female patients aged 20-30 years were diagnosed with SARS-CoV-2 postvaccination; all fully recovered. CONCLUSIONS: This is an important contribution to research on SARS-CoV-2 vaccine safety in adolescents with RMDs and adults with JIA. It is important to note the low frequency of disease flares, serious AEs and SARS-CoV-2 reinfection seen in both populations, although the dataset is limited by its size.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent475230
dc.identifier.doi10.1136/rmdopen-2022-002322
dc.identifier.issn2044-6055
dc.identifier.otherPURE: 46124232
dc.identifier.otherPURE UUID: 1887e38b-89f7-44cc-872e-044b221846e3
dc.identifier.otherScopus: 85135224372
dc.identifier.otherPubMed: 35908834
dc.identifier.urihttp://hdl.handle.net/10362/143607
dc.identifier.urlhttps://www.scopus.com/pages/publications/85135224372
dc.language.isoeng
dc.peerreviewedyes
dc.subjectArthritis, Juvenile
dc.subjectCOVID-19
dc.subjectVaccination
dc.subjectRheumatology
dc.subjectImmunology and Allergy
dc.subjectImmunology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleSARS-CoV-2 vaccine safety in adolescents with inflammatory rheumatic and musculoskeletal diseases and adults with juvenile idiopathic arthritisen
dc.title.subtitledata from the EULAR COVAX physician-reported registryen
dc.typejournal article
degois.publication.issue2
degois.publication.titleRMD Open
degois.publication.volume8
dspace.entity.typePublication
rcaap.rightsopenAccess

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