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Effects of a bloodless diet on fitness and malaria susceptibility in Anopheles mosquitoes from Burkina Faso

2026-12Artigo científico Acesso aberto
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dc.contributor.authorde Sales Hien, Domonbabele François
dc.contributor.authorSare, Issiaka
dc.contributor.authorSib, Auguste Marie Ange Paul
dc.contributor.authorPoda, Bèwadéyir Serge
dc.contributor.authorVelez, Rita
dc.contributor.authorMarques, Joana
dc.contributor.authorSilveira, Henrique
dc.contributor.authorDiabate, Abdoulaye
dc.contributor.authorBilgo, Etienne M.
dc.contributor.institutionLaboratório Associado de Translacção e Inovação para a Saúde Global - LA Real (Pólo IHMT)
dc.contributor.institutionVector borne diseases and pathogens (VBD)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.pblNature Publishing Group
dc.date.accessioned2026-06-21T13:31:02Z
dc.date.available2026-06-21T13:31:02Z
dc.date.issued2026-12
dc.descriptionFunding text: The research received financial support from Fundação para a Ciência e Tecnologia and Aga-Khan Development Network (MosqDiet_FCT AGAKHAN/541725581/2019), and IHI (Training and Capacity Building Unit). J.M. and H.S. are supported by the Fundação para a Ciência e a Tecnologia (FCT Portugal) by funds to GHTM/IHMT-NOVA (GHTM-UID GHTM UID/04413/2020). J.M. is recipient of a contract by FCT (https://doi.org/10.54499/CEECIND/00450/2017/CP1415/CT0001. Publisher Copyright: © The Author(s) 2026.
dc.description.abstractEmerging resistance in malaria vectors and parasites has accelerated the development of novel control strategies such as the Sterile Insect Technique and Wolbachia-based approaches, which require large-scale mosquito rearing. These methods traditionally rely on vertebrate Blood, raising ethical and logistical concerns. This study evaluated the effects of a BLOODless™ on wing size, longevity, and Plasmodium falciparum susceptibility in Anopheles coluzzii and An. gambiae from Burkina Faso, and the Kisumu An. gambiae strain. Blood and Bloodless-reared mosquitoes were compared across seven generations. Wing size was unaffected by diet in the 3rd and 7th generations, though sex impacted size in the 3rd generation only. A diet-species interaction was detected in the 7th generation. Plasmodium falciparum infection rates were similar in the 3rd generation, but by the 6th, Blood-fed mosquitoes showed higher oocyst prevalence, though intensity remained unchanged. Infection outcomes were species-dependent only at this later stage. Longevity, initially comparable across groups, increased significantly in Bloodless-fed mosquitoes by the 7th generation. Species had no effect on survival. A Blood-free diet enables sustained mosquito rearing while preserving traits essential for malaria research, providing an ethical, effective alternative to vertebrate Blood in vector control and experimental programs.en
dc.description.versionpublishersversion
dc.description.versionepub_ahead_of_print
dc.format.extent1763410
dc.identifier.doi10.1038/s41598-026-40458-x
dc.identifier.issn2045-2322
dc.identifier.otherPURE: 163257293
dc.identifier.otherPURE UUID: 4db18ff1-831a-4c7b-8c31-52155b5bc572
dc.identifier.otherScopus: 105033361332
dc.identifier.otherWOS: 001714879000002
dc.identifier.otherPubMed: 41703288
dc.identifier.otherPubMedCentral: PMC12979765
dc.identifier.otherORCID: /0000-0002-7939-772X/work/218363948
dc.identifier.otherORCID: /0000-0003-1827-2912/work/218364044
dc.identifier.urihttp://hdl.handle.net/10362/203936
dc.identifier.urlhttps://www.scopus.com/pages/publications/105033361332
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBloodless diet
dc.subjectLongevity, Anopheles mosquitoes
dc.subjectSusceptibility to Plasmodium falciparum
dc.subjectWing length
dc.subjectGeneral
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEffects of a bloodless diet on fitness and malaria susceptibility in Anopheles mosquitoes from Burkina Fasoen
dc.typejournal article
degois.publication.issue1
degois.publication.titleScientific Reports
degois.publication.volume16
dspace.entity.typePublication
rcaap.rightsopenAccess

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