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Nucleic acid-based therapy for brain tumor

2022-10Artigo científico Acesso aberto
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dc.contributor.authorZhang, Zixia
dc.contributor.authorConniot, João
dc.contributor.authorAmorim, Joana
dc.contributor.authorJin, Yiliang
dc.contributor.authorPrasad, Rajendra
dc.contributor.authorYan, Xiyun
dc.contributor.authorFan, Kelong
dc.contributor.authorConde, João
dc.contributor.authorConde, João
dc.contributor.institutionCentre for Toxicogenomics and Human Health (ToxOmics)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblElsevier
dc.date.accessioned2022-08-25T22:21:19Z
dc.date.available2022-08-25T22:21:19Z
dc.date.issued2022-10
dc.description.abstractNucleic acid-based therapy emerges as a powerful weapon for the treatment of tumors thanks to its direct, effective, and lasting therapeutic effect. Encouragingly, continuous nucleic acid-based drugs have been approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA). Despite the tremendous progress, there are few nucleic acid-based drugs for brain tumors in clinic. The most challenging problems lie on the instability of nucleic acids, difficulty in traversing the biological barriers, and the off-target effect. Herein, nucleic acid-based therapy for brain tumor is summarized considering three aspects: (i) the therapeutic nucleic acids and their applications in clinical trials; (ii) the various administration routes for nucleic acid delivery and the respective advantages and drawbacks. (iii) the strategies and carriers for improving stability and targeting ability of nucleic acid drugs. This review provides thorough knowledge for the rational design of nucleic acid-based drugs against brain tumor.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent4215015
dc.identifier.doi10.1016/j.jconrel.2022.08.014
dc.identifier.issn0168-3659
dc.identifier.otherPURE: 46066726
dc.identifier.otherPURE UUID: 34788c8d-b922-4164-8973-9dff5173efea
dc.identifier.otherPubMed: 35970297
dc.identifier.otherScopus: 85135948829
dc.identifier.otherWOS: 000848023900005
dc.identifier.urihttp://hdl.handle.net/10362/143307
dc.language.isoeng
dc.peerreviewedyes
dc.subjectNucleic acid-based therapy
dc.subjectBrain tumor
dc.subjectBlood brain barrier
dc.subjectDrug delivery
dc.subjectCarriers
dc.titleNucleic acid-based therapy for brain tumoren
dc.title.subtitleChallenges and strategiesen
dc.typejournal article
degois.publication.firstPage80
degois.publication.lastPage92
degois.publication.titleJournal of Controlled Release
degois.publication.volume350
dspace.entity.typePublication
person.familyNameConde
person.givenNameJoão
person.identifier807432
person.identifier.ciencia-idA71C-B10E-255E
person.identifier.orcid0000-0001-8422-6792
person.identifier.ridF-2231-2011
person.identifier.scopus-author-id56992468300
rcaap.rightsopenAccess
relation.isAuthorOfPublication33ca4178-1b25-4b5e-ae16-b2500abe4c58
relation.isAuthorOfPublication.latestForDiscovery33ca4178-1b25-4b5e-ae16-b2500abe4c58

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