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Long-term follow-up of subthalamic nucleus deep brain stimulation in patients with Parkinson's disease

2024-01Artigo científico Acesso aberto
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dc.contributor.authorBarbosa, Raquel
dc.contributor.authorGuedes, Leonor Correia
dc.contributor.authorCattoni, Maria Begoña
dc.contributor.authorLobo, Patricia Pita
dc.contributor.authorCaldas, Ana Castro
dc.contributor.authorFabbri, Margherita
dc.contributor.authorBastos, Paulo
dc.contributor.authorValadas, Anabela
dc.contributor.authorCarvalho, Herculano
dc.contributor.authorAlbuquerque, Luisa
dc.contributor.authorReimão, Sofia
dc.contributor.authorFerreira, A. Gonçalves
dc.contributor.authorFerreira, Joaquim J.
dc.contributor.authorRosa, Mário Miguel
dc.contributor.authorCoelho, Miguel
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblElsevier
dc.date.accessioned2023-11-28T22:38:01Z
dc.date.available2023-11-28T22:38:01Z
dc.date.issued2024-01
dc.descriptionFunding Information: This work was supported by Fundação para a Ciência e Tecnologia (FCT) through a Ph.D. Scholarship ( SFRH/BD/143797/2019 ) and Prémio João Lobo Antunes by Santa Casa da Misericórdia de Lisboa. Funding Information: This work was supported by Fundação para a Ciência e Tecnologia (FCT) through a Ph.D. Scholarship (SFRH/BD/143797/2019) and Prémio João Lobo Antunes by Santa Casa da Misericórdia de Lisboa. Publisher Copyright: © 2023
dc.description.abstractBackground: Data on the long-term survival and incidence of disability milestones after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) is limited. Objectives: To estimate mortality and assess the frequency/time-to-development of disability milestones (falls, freezing, hallucinations, dementia, and institutionalization) among PD patients post STN-DBS. Methods: A longitudinal retrospective study of patients undergoing STN-DBS. For mortality, Cox proportional hazards regression analysis was performed. For disease milestones, competing risk analyses were performed and cumulative incidence functions reported. The strength of association between baselines features and event occurrence was calculated based on adjusted hazard ratios. Results: The overall mortality for the 109 patients was 16 % (62.1 ± 21.3 months after surgery). Falls (73 %) and freezing (47 %) were both the earliest (40.4 ± 25.4 and 39.6 ± 28.4 months, respectively) and most frequent milestones. Dementia (34 %) and hallucinations (32 %) soon followed (56.2 ± 21.2 and mean 60.0 ± 20.7 months after surgery, respectively). Higher ADL scores in the OFF state and higher age at surgery were associated with falls, freezing, dementia and institutionalization. Conclusions: Long-term mortality rate is low after STN-DBS. Disease milestones occur later during the disease course, with motor milestones appearing first and at a higher frequency than cognitive ones.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent982172
dc.identifier.doi10.1016/j.parkreldis.2023.105921
dc.identifier.issn1353-8020
dc.identifier.otherPURE: 76898691
dc.identifier.otherPURE UUID: c3e014fb-223b-411d-a2a9-a53d1bfbe240
dc.identifier.otherScopus: 85176761317
dc.identifier.otherPubMed: 37976978
dc.identifier.urihttp://hdl.handle.net/10362/160678
dc.identifier.urlhttps://www.scopus.com/pages/publications/85176761317
dc.language.isoeng
dc.peerreviewedyes
dc.subjectDeep brain stimulation
dc.subjectDisability
dc.subjectMilestones
dc.subjectMortality
dc.subjectParkinson's disease
dc.subjectSubthalamic nucleus
dc.subjectNeurology
dc.subjectGeriatrics and Gerontology
dc.subjectClinical Neurology
dc.titleLong-term follow-up of subthalamic nucleus deep brain stimulation in patients with Parkinson's diseaseen
dc.title.subtitleAn analysis of survival and disability milestonesen
dc.typejournal article
degois.publication.titleParkinsonism and Related Disorders
degois.publication.volume118
dspace.entity.typePublication
rcaap.rightsopenAccess

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