Logo do repositório
 
Publicação

Advanced Methods for Natural Products Discovery

2023-05-19Recensão Acesso aberto
Ver registo simples
dc.contributor.authorGaudêncio, Susana P.
dc.contributor.authorBayram, Engin
dc.contributor.authorLukić Bilela, Lada
dc.contributor.authorCueto, Mercedes
dc.contributor.authorDíaz-Marrero, Ana R.
dc.contributor.authorHaznedaroglu, Berat Z.
dc.contributor.authorJimenez, Carlos
dc.contributor.authorMandalakis, Manolis
dc.contributor.authorPereira, Florbela
dc.contributor.authorReyes, Fernando
dc.contributor.authorTasdemir, Deniz
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2023-06-12T22:20:04Z
dc.date.available2023-06-12T22:20:04Z
dc.date.issued2023-05-19
dc.descriptionFunding Information: This publication is based upon work from COST Action CA18238 (Ocean4Biotech), funded by the European Cooperation in Science and Technology (COST) Program in the period 2019–2023. SPG: This work is financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. LLB: The publication is part of a project that has received funding from the Erasmus + Project No. ECOBIAS_609967-EPP-1-2019-1-RS-EPPKA2-CBHE-JP; GA.2019-1991/001-001. Development of master curricula in ecological monitoring and aquatic bioassessment for Western Balkans HEIs/ECOBIAS. CJ: This work was supported by grants PID2021-122732OB-C22 from MCIN/AEI/10.13039/501100011033/FEDER “A way to make Europe” (AEI, Spanish State Agency for Research and FEDER Programme from the European Union) and RTI2018-093634-B-C22 from the State Agency for Research (AEI) of Spain, co-funded by the FEDER Programme from the European Union, and BLUEBIOLAB (0474_BLUEBIOLAB_1_E), Programme INTERREG V A of Spain-Portugal (POCTEP). FP: This work is financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., for an Assistant Research Position (CEECIND/01649/2021). MC: INTERREG-MAC2/1.1b/279 (AHIDAGRO) and the Ministerio de Ciencia e Innovación (Spain) (grant PID2020-115979RR-C32). ARDM is supported with funds from Proyecto Intramural Especial CSIC [Ref. 202280I032]. Publisher Copyright: © 2023 by the authors.
dc.description.abstractNatural Products (NP) are essential for the discovery of novel drugs and products for numerous biotechnological applications. The NP discovery process is expensive and time-consuming, having as major hurdles dereplication (early identification of known compounds) and structure elucidation, particularly the determination of the absolute configuration of metabolites with stereogenic centers. This review comprehensively focuses on recent technological and instrumental advances, highlighting the development of methods that alleviate these obstacles, paving the way for accelerating NP discovery towards biotechnological applications. Herein, we emphasize the most innovative high-throughput tools and methods for advancing bioactivity screening, NP chemical analysis, dereplication, metabolite profiling, metabolomics, genome sequencing and/or genomics approaches, databases, bioinformatics, chemoinformatics, and three-dimensional NP structure elucidation.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent66
dc.format.extent7807912
dc.identifier.doi10.3390/md21050308
dc.identifier.issn1660-3397
dc.identifier.otherPURE: 63548778
dc.identifier.otherPURE UUID: 27c577af-f9f7-4905-98f3-72d67af25e79
dc.identifier.otherScopus: 85160360049
dc.identifier.otherWOS: 000996829500001
dc.identifier.otherPubMed: 37233502
dc.identifier.otherPubMedCentral: PMC10222211
dc.identifier.urihttp://hdl.handle.net/10362/153864
dc.identifier.urlhttps://www.scopus.com/pages/publications/85160360049
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.subjectblue biotechnology
dc.subjectcomputer assisted structure elucidation (CASE)
dc.subjectdereplication
dc.subjectGlobal Natural Product Social Molecular Networking (GNPS)
dc.subjecthigh throughput next-generation sequencing (HT/NGS)
dc.subjecthigh-throughput screening (HTS)
dc.subjectinformatic chemometrics
dc.subjectmode of action (MoA)
dc.subjectmolecular networking
dc.subjectnatural products
dc.subjectnatural products databases
dc.subjectrelative and absolute configuration determination in structure elucidation
dc.subjectPharmaceutical Science
dc.subjectDrug Discovery
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.titleAdvanced Methods for Natural Products Discoveryen
dc.title.subtitleBioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidationen
dc.typereview
degois.publication.issue5
degois.publication.titleMarine Drugs
degois.publication.volume21
dspace.entity.typePublication
oaire.awardNumberUIDP/04378/2020
oaire.awardNumberUIDB/04378/2020
oaire.awardNumberUIDB/50006/2020
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication38373452-5c9c-4724-8def-f03314ecce0e
relation.isProjectOfPublicatione07cf232-4705-4b5b-b2c4-af8f25311076
relation.isProjectOfPublicationadc84c24-ba1d-4bcd-b753-2128ce9a5faa
relation.isProjectOfPublication.latestForDiscovery38373452-5c9c-4724-8def-f03314ecce0e

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Advanced_Methods_for_Natural_Products.pdf
Tamanho:
7.45 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

Home collection (FCT)