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Lowering polyhydroxyalkanoate bioproduction costs in mixed cultures through integrated optimization of organic loading rate, sludge retention time and biomass withdrawal

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dc.contributor.authorCruz, Rafaela A.P.
dc.contributor.authorOehmen, Adrian
dc.contributor.authorReis, Maria A.M.
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionFaculdade de Ciências e Tecnologia (FCT)
dc.contributor.pblElsevier
dc.date.accessioned2025-09-04T22:36:26Z
dc.date.available2025-09-04T22:36:26Z
dc.date.issued2025
dc.descriptionThe authors further acknowledge Elsa Mora, M\u00F3nica Centeio and Elisabete Freitas for their contribution with quantitative analysis and Elisabete Freitas for help with microbiology samples. © 2025 The Authors. Published by Elsevier B.V. on behalf of The Korean Society of Industrial and Engineering Chemistry.
dc.description.abstractPolyhydroxyalkanoates (PHA) are a sustainable alternative to conventional plastics, where mixed microbial cultures can be advantageous for PHA production from industrial waste streams, but lower costs are necessary to facilitate industrial application. This study assesses a novel optimisation strategy for the biomass withdrawal, organic loading rate and solids retention time, with the purpose of lowering bioproduction costs. Conventional and feast-phase biomass withdrawal strategies were compared to determine the most cost-effective operational option. Results demonstrated that increasing the organic loading rate led to an improvement of PHA productivity in each selection reactor, due to increased growth. It was observed that at low solids retention time, the incorporation of an accumulation stage did not improve the productivity of the polyhydroxyalkanoate production process using the feast-phase biomass withdrawal strategy, reducing capital costs. Economic assessment of the two different operational modes was performed, where the results demonstrated that the feast-phase biomass withdrawal strategy at an SRT of 0.8 d was the configuration resulting in the lowest total annual costs and lowest break-even PHA price (1.88 €/kg PHA-crude), due to elimination of the accumulation stage. Overall, this work contributes towards sustainable and cost-effective polyhydroxyalkanoate production from wastes in mixed cultures.en
dc.description.versionproof
dc.description.versioninpress
dc.format.extent1646316
dc.identifier.doi10.1016/j.jiec.2025.08.030
dc.identifier.issn1226-086X
dc.identifier.otherPURE: 128701577
dc.identifier.otherPURE UUID: ad876e74-b50b-4862-a0a9-4d6fe6df4549
dc.identifier.otherScopus: 105013650118
dc.identifier.urihttp://hdl.handle.net/10362/187559
dc.identifier.urlhttps://www.scopus.com/pages/publications/105013650118
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: info:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F04378%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F110673%2F2015/PT
dc.relationIntegrating resource recovery of value-added biopolymers into biological wastewater treatment systems
dc.subjectBiomass Withdrawal (BW)
dc.subjectBioplastics
dc.subjectCost assessment
dc.subjectMixed microbial cultures (MMC)
dc.subjectPHA productivity
dc.subjectPolyhydroxyalkanoate (PHA)
dc.subjectGeneral Chemical Engineering
dc.titleLowering polyhydroxyalkanoate bioproduction costs in mixed cultures through integrated optimization of organic loading rate, sludge retention time and biomass withdrawalen
dc.typejournal article
degois.publication.titleJournal of Industrial and Engineering Chemistry
dspace.entity.typePublication
oaire.awardNumberSFRH/BD/110673/2015
oaire.awardTitleIntegrating resource recovery of value-added biopolymers into biological wastewater treatment systems
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F110673%2F2015/PT
oaire.fundingStreamOE
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublicationebb82bb0-8577-414d-bf2d-161771350535
relation.isProjectOfPublication.latestForDiscoveryebb82bb0-8577-414d-bf2d-161771350535

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