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Poloxamer-based injectable hydrogels as matrices for localized anti-inflammatory drug delivery in meniscus injuries

2026Artigo científico Acesso aberto
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dc.contributor.authorTuszynska, Marta
dc.contributor.authorGonçalves, Adriana
dc.contributor.authorSkopinska-Wisniewska, Joanna
dc.contributor.authorSoares, Paula I.P.
dc.contributor.authorBajek, Anna
dc.contributor.institutionCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
dc.contributor.institutionDCM - Departamento de Ciência dos Materiais
dc.contributor.pblRSC - Royal Society of Chemistry
dc.date.accessioned2026-05-28T13:40:01Z
dc.date.available2026-05-28T13:40:01Z
dc.date.issued2026
dc.descriptionPublisher Copyright: This journal is © The Royal Society of Chemistry, 2026
dc.description.abstractPoloxamer-based hydrogels, composed of thermoreversible triblock copolymers, are promising drug delivery systems due to their ability to transition from a liquid to a gel state at physiological temperatures, enabling minimally invasive injection and localized, sustained release of therapeutic agents. In this study, poloxamer hydrogels were prepared with diclofenac sodium salt and paracetamol as model anti-inflammatory drugs, and characterized for morphology, osmolarity, pH, and temperature sensitivity. Drug loading optimization was performed to ensure homogeneous dispersion, and release kinetics were evaluated by spectrophotometric analysis, with mathematical modeling used to describe and predict drug release mechanisms from the hydrogel matrix. The optimized poloxamer gels exhibited an appropriate sol–gel transition near body temperature (26–37 °C), stable pH, and osmolarity suitable for biomedical use. Drug release profiles showed controlled, sustained release of both diclofenac sodium and paracetamol over extended periods, with mathematical modeling indicating that diffusion-based mechanisms predominated in drug release from the hydrogel matrix, validating the system design for targeted, localized therapy. These findings demonstrate that poloxamer-based injectable hydrogels effectively deliver anti-inflammatory agents with controlled release, representing a versatile platform for localized drug delivery in regenerative medicine and orthopedic applications, particularly for intra-articular treatment of musculoskeletal disorders, thereby supporting improved therapeutic outcomes while minimizing systemic exposure and associated side effects.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent13
dc.format.extent1679151
dc.identifier.doi10.1039/d6ra02085b
dc.identifier.issn2046-2069
dc.identifier.otherPURE: 163574524
dc.identifier.otherPURE UUID: 08e722c4-9b4d-4109-a8ec-5effbec61d8c
dc.identifier.otherScopus: 105037752607
dc.identifier.otherWOS: 001753914500001
dc.identifier.otherPubMed: 42077798
dc.identifier.otherPubMedCentral: PMC13133859
dc.identifier.urihttp://hdl.handle.net/10362/203532
dc.identifier.urlhttps://www.scopus.com/pages/publications/105037752607
dc.identifier.urlhttps://www.webofscience.com/wos/woscc/full-record/WOS:001753914500001
dc.language.isoeng
dc.peerreviewedyes
dc.subjectGeneral Chemistry
dc.subjectGeneral Chemical Engineering
dc.titlePoloxamer-based injectable hydrogels as matrices for localized anti-inflammatory drug delivery in meniscus injuriesen
dc.typejournal article
degois.publication.firstPage21333
degois.publication.issue23
degois.publication.lastPage21345
degois.publication.titleRSC Advances
degois.publication.volume16
dspace.entity.typePublication
rcaap.rightsopenAccess

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