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Smart multifunctional hydrogels with shape memory, conductivity, self-healing, and adhesive properties for biomedical applications

2026-04Artigo científico Acesso aberto
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dc.contributor.authorHuong, Ha
dc.contributor.authorLuu, Cuong Hung
dc.contributor.authorPhan, V. H.Giang
dc.contributor.authorJanarthanan, Gopinathan
dc.contributor.authorHuynh, Ngoc Thuy
dc.contributor.authorNguyen, Hieu Trung
dc.contributor.authorHa, Nhu Y.Ngoc
dc.contributor.authorTa, Hang Thu
dc.contributor.authorZhou, Qihui
dc.contributor.authorVijayavenkataraman, Sanjairaj
dc.contributor.authorConde, João
dc.contributor.authorThambi, Thavasyappan
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblElsevier
dc.date.accessioned2026-03-12T11:01:04Z
dc.date.available2026-03-12T11:01:04Z
dc.date.issued2026-04
dc.descriptionPublisher Copyright: © 2026 The Author(s).
dc.description.abstractShape memory hydrogels often suffer from slow recovery, mechanical weakness, and poor stability under physiological environments, limiting their biomedical applicability. Herein, we developed a multifunctional smart hydrogel composed of gelatin, chitosan, alginate, and montmorillonite clay (GCAM), engineered for advanced biomedical applications. The hydrogel exhibited ion-responsive shape memory behavior, through calcium-mediated “egg-box” fixation and bicarbonate-induced recovery, achieving robust recovery of complex geometries. GCAM hydrogels showed a high swelling ratio (324.1 ± 22.4%), an interconnected porous structure, excellent skin adhesiveness without leaving residue, and controlled degradation (14.1 ± 0.3% weight loss by day 20 and 85.4 ± 2.1% by day 60 in PBS). The material exhibited rapid self-healing (≤ 1 h), recovering ∼90% tensile strength and maintaining electrical conductivity to enabling LED illumination in a closed circuit. Enoxaparin was successfully encapsulated and released in a sustained manner over 14 days, with cumulative release of 91.6 ± 5.4%. The hydrogel showed strong biocompatibility with viability exceeding 80% at 80 μg/mL in mouse vascular endothelial cells, alongside excellent hemocompatibility, and the promotion in vascularization in the CAM assay. Collectively, these findings highlight the multifunctional potential of the GCAM hydrogel for advanced biomedical and wearable applications.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent8046562
dc.identifier.doi10.1016/j.matdes.2026.115736
dc.identifier.issn0264-1275
dc.identifier.otherPURE: 157103328
dc.identifier.otherPURE UUID: 299f7fa8-a248-4dd5-a3c6-71ee28e0d794
dc.identifier.otherScopus: 105031755019
dc.identifier.urihttp://hdl.handle.net/10362/201309
dc.identifier.urlhttps://www.scopus.com/pages/publications/105031755019
dc.language.isoeng
dc.peerreviewedyes
dc.subjectControlled release
dc.subjectSelf-healing
dc.subjectShape memory hydrogels
dc.subjectStimuli-responsive materials
dc.subjectGeneral Materials Science
dc.subjectMechanics of Materials
dc.subjectMechanical Engineering
dc.titleSmart multifunctional hydrogels with shape memory, conductivity, self-healing, and adhesive properties for biomedical applicationsen
dc.typejournal article
degois.publication.titleMaterials and Design
degois.publication.volume264
dspace.entity.typePublication
rcaap.rightsopenAccess

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