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Changes in Serum Metabolome Following Low-Energy Diet-Induced Weight Loss in Women with Overweight and Prediabetes

2024-08Artigo científico Acesso aberto
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dc.contributor.authorRelva, Bárbara
dc.contributor.authorSamuelsson, Linda M.
dc.contributor.authorDuarte, Iola F.
dc.contributor.authorFasol, Ulrike
dc.contributor.authorEdwards, Patrick J.B.
dc.contributor.authorFogelholm, Mikael
dc.contributor.authorRaben, Anne
dc.contributor.authorPoppitt, Sally D.
dc.contributor.authorSilvestre, Marta P.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2024-09-04T22:20:36Z
dc.date.available2024-09-04T22:20:36Z
dc.date.issued2024-08
dc.description.abstractAs obesity develops, metabolic changes increase the risk of non-communicable diseases such as type 2 diabetes (T2D). Weight loss is crucial for improving health in T2D and cardiometabolic conditions. However, weight loss rates vary between individuals, even with identical diets or energy restrictions, highlighting the need to identify markers or predictors of weight loss success to enhance intervention outcomes. Using nuclear magnetic resonance (NMR) spectroscopy-based metabolomics, we investigated the change in serum polar metabolites in 28 women with overweight or obesity and prediabetes who completed an 8-week low-energy diet (LED) as part of the PREVIEW (PREVention of diabetes through lifestyle intervention and population studies in Europe and around the World) clinical trial. We aimed to characterize the metabolic shift in substrate oxidation under fixed energy intake (~4 MJ/day) and its relation to weight loss success. Nine of the thirty-four serum metabolites identified significantly changed during the LED phase: 3-hydroxybutyrate, O-acetylcarnitine, 2-hydroxybutyrate, mannose, dimethyl sulfone and isobutyrate increased, whilst choline, creatine and tyrosine decreased. These results confirmed a shift towards lipid oxidation, but no metabolites predicted the response to the LED-induced weight loss. Further studies in larger populations are required to validate these metabolites as biomarkers of diet exposure.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent571281
dc.identifier.doi10.3390/metabo14080401
dc.identifier.issn2218-1989
dc.identifier.otherPURE: 99086204
dc.identifier.otherPURE UUID: 59115e74-22a3-4840-98bb-3baf8e694eba
dc.identifier.otherScopus: 85202505956
dc.identifier.otherORCID: /0000-0001-9327-2897/work/166847307
dc.identifier.otherPubMed: 39195497
dc.identifier.urihttp://hdl.handle.net/10362/171173
dc.identifier.urlhttps://www.scopus.com/pages/publications/85202505956
dc.language.isoeng
dc.peerreviewedyes
dc.subjectlow-energy diet
dc.subjectmetabolomics
dc.subjectNMR spectroscopy
dc.subjectobesity
dc.subjectpolar metabolites
dc.subjectprediabetes
dc.subjectweight loss
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectBiochemistry
dc.subjectMolecular Biology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleChanges in Serum Metabolome Following Low-Energy Diet-Induced Weight Loss in Women with Overweight and Prediabetesen
dc.title.subtitleA PREVIEW-New Zealand Sub-Studyen
dc.typejournal article
degois.publication.issue8
degois.publication.titleMetabolites
degois.publication.volume14
dspace.entity.typePublication
rcaap.rightsopenAccess

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