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Hospitalization Risk Due to Respiratory Illness Associated with Genetic Variation at IFITM3 in Patients with Influenza A(H1N1)pdm09 Infection

2016-06-28Artigo científico Acesso aberto
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dc.contributor.authorGaio, Vania
dc.contributor.authorNunes, Baltazar
dc.contributor.authorPechirra, Pedro
dc.contributor.authorConde, Patricia
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorDias, Carlos Matias
dc.contributor.authorBarreto, Marta
dc.contributor.institutionCentro de Investigação em Saúde Pública (CISP/PHRC)
dc.contributor.institutionEscola Nacional de Saúde Pública (ENSP)
dc.contributor.pblPLOS - Public Library of Science
dc.date.accessioned2018-02-19T23:02:56Z
dc.date.available2018-02-19T23:02:56Z
dc.date.issued2016-06-28
dc.description.abstractBackground Recent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs12252 variant and the course of influenza infection. However, it is not clear whether the reported association relates to influenza infection severity. The aim of this study was to estimate the hospitalization risk associated with this variant in Influenza Like Illness (ILI) patients during the H1N1 pandemic influenza. Methods A case-control genetic association study was performed, using nasopharyngeal/oropharyngeal swabs collected during the H1N1 pandemic influenza. Laboratory diagnosis of influenza infection was performed by RT-PCR, the IFITM3 rs12252 was genotyped by RFLP and tested for association with hospitalization. Conditional logistic regression was performed to calculate the confounder-adjusted odds ratio of hospitalization associated with IFITM3 rs12252. Results We selected 312 ILI cases and 624 matched non-hospitalized controls. Within ILI Influenza A(H1N1)pdm09 positive patients, no statistical significant association was found between the variant and the hospitalization risk (Adjusted OR: 0.73 (95% CI: 0.33-1.50)). Regarding ILI Influenza A(H1N1) pdm09 negative patients, CT/CC genotype carriers had a higher risk of being hospitalized than patients with TT genotype (Adjusted OR: 2.54 (95% CI: 1.54-4.19)). Conclusions The IFITM3 rs12252 variant was associated with respiratory infection hospitalization but not specifically in patients infected with Influenza A(H1N1) pdm09.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent10
dc.format.extent440273
dc.identifier.doi10.1371/journal.pone.0158181
dc.identifier.issn1932-6203
dc.identifier.otherPURE: 1945531
dc.identifier.otherPURE UUID: 8cdf86da-bd31-4ad6-bbe4-deecea7cdc8a
dc.identifier.otherWOS: 000378858900041
dc.identifier.otherPubMed: 27351739
dc.identifier.otherScopus: 84978039656
dc.identifier.urihttp://hdl.handle.net/10362/30836
dc.language.isoeng
dc.peerreviewedyes
dc.subjectA H1N1 VIRUS
dc.subjectSUSCEPTIBILITY
dc.titleHospitalization Risk Due to Respiratory Illness Associated with Genetic Variation at IFITM3 in Patients with Influenza A(H1N1)pdm09 Infectionen
dc.title.subtitleA Case-Control Studyen
dc.typejournal article
degois.publication.issue6
degois.publication.titlePLoS ONE
degois.publication.volume11
dspace.entity.typePublication
rcaap.rightsopenAccess

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