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Ageing affects the CD4+ T cell polarization and mucosal tropism induced by TLR2/TLR4-activated dendritic cells

2025-07-01Artigo científico Acesso aberto
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dc.contributor.authorZúquete, Sara
dc.contributor.authorFerreira, Mariana
dc.contributor.authorDelgado, Inês L.S.
dc.contributor.authorRosa, Maria Teresa
dc.contributor.authorMendes, Ana Catarina
dc.contributor.authorSantos, Dulce
dc.contributor.authorNolasco, Sofia
dc.contributor.authorGraca, Luis
dc.contributor.authorLeitão, Alexandre
dc.contributor.authorBasto, Afonso P.
dc.contributor.institutionFaculdade de Ciências e Tecnologia (FCT)
dc.contributor.pblOxford University Press
dc.date.accessioned2025-09-04T22:31:32Z
dc.date.available2025-09-04T22:31:32Z
dc.date.issued2025-07-01
dc.descriptionFunding was also provided by Fundaci\u00F3n la Caixa through the project HR22-00741. Publisher Copyright: © The Author(s) 2025. Published by Oxford University Press on behalf of Society for Leukocyte Biology.
dc.description.abstractToll-like receptor (TLR)2 activation induces aldehyde dehydrogenase enzymes in nonmucosal dendritic cells (DCs) enabling them to metabolize vitamin A into all-trans retinoic acid, which induces the expression of mucosal homing molecules (α4β7 and CCR9) in the activated T cells. Recently, we have shown that the simultaneous activation of nonmucosal DCs through TLR2 and TLR4 maintains such capacity while reinforcing the polarization of primed CD4+ T cells towards Th1. Here, we observed that TLR2/TLR4 stimulation of aged DCs leads to the production of less TNFα and more IL-10 and that CD4+ T cells primed by those DCs express lower levels of the mucosal homing receptor CCR9 and produce less type-1 (IFNγ) and more type-2 (IL-4 and IL-13) cytokines. These results emphasize the importance of considering the age-related alterations in DC function when developing novel immunomodulation strategies that rely on the DC-T cell crosstalk through stimulation of pattern recognition receptors.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent588634
dc.identifier.doi10.1093/jleuko/qiaf096
dc.identifier.issn0741-5400
dc.identifier.otherPURE: 128700252
dc.identifier.otherPURE UUID: 5791d496-6a5d-425c-a42f-65ad8870fb84
dc.identifier.otherScopus: 105011375324
dc.identifier.otherPubMed: 40576094
dc.identifier.urihttp://hdl.handle.net/10362/187556
dc.identifier.urlhttps://www.scopus.com/pages/publications/105011375324
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCVT-CVT%2F31840%2F2017/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos IC&DT em Todos os Domínios Científicos/PTDC%2FCVT-CVT%2F4599%2F2021/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022/2022.04903.PTDC/PT
dc.relationModulation of human antibody responses by T follicular helper subsets
dc.relationCenter for Interdisciplinary Research in Animal Health
dc.relationCentre for Interdisciplinary Research in Animal Health
dc.subjectaging
dc.subjectdendritic cells
dc.subjectintestine
dc.subjecttoll-like receptor 2
dc.subjecttoll-like receptor 4
dc.subjectImmunology and Allergy
dc.subjectImmunology
dc.subjectCell Biology
dc.titleAgeing affects the CD4+ T cell polarization and mucosal tropism induced by TLR2/TLR4-activated dendritic cellsen
dc.typejournal article
degois.publication.issue7
degois.publication.titleJournal of Leukocyte Biology
degois.publication.volume117
dspace.entity.typePublication
oaire.awardNumberPTDC/CVT-CVT/4599/2021
oaire.awardNumber2022.04903.PTDC
oaire.awardNumberLA/P/0059/2020
oaire.awardNumberUID/CVT/00276/2019
oaire.awardNumberUIDB/00276/2020
oaire.awardTitleModulation of human antibody responses by T follicular helper subsets
oaire.awardTitleCenter for Interdisciplinary Research in Animal Health
oaire.awardTitleCentre for Interdisciplinary Research in Animal Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos IC&DT em Todos os Domínios Científicos/PTDC%2FCVT-CVT%2F4599%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022/2022.04903.PTDC/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0059%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FCVT%2F00276%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00276%2F2020/PT
oaire.fundingStreamConcurso de Projetos IC&DT em Todos os Domínios Científicos
oaire.fundingStreamConcurso de Projetos de I&D em Todos os Domínios Científicos - 2022
oaire.fundingStreamConcurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
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