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Carboxyhemoglobin (COHb)

2023-05-31Recensão Acesso aberto
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dc.contributor.authorCarrola, André
dc.contributor.authorRomão, Carlos C.
dc.contributor.authorVieira, Helena L. A.
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionInstituto de Tecnologia Química e Biológica António Xavier (ITQB)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2023-09-19T22:15:51Z
dc.date.available2023-09-19T22:15:51Z
dc.date.issued2023-05-31
dc.descriptionPublisher Copyright: © 2023 by the authors.
dc.description.abstractCarbon monoxide (CO) is a cytoprotective endogenous gas that is ubiquitously produced by the stress response enzyme heme-oxygenase. Being a gas, CO rapidly diffuses through tissues and binds to hemoglobin (Hb) increasing carboxyhemoglobin (COHb) levels. COHb can be formed in erythrocytes or in plasma from cell-free Hb. Herein, it is discussed as to whether endogenous COHb is an innocuous and inevitable metabolic waste product or not, and it is hypothesized that COHb has a biological role. In the present review, literature data are presented to support this hypothesis based on two main premises: (i) there is no direct correlation between COHb levels and CO toxicity, and (ii) COHb seems to have a direct cytoprotective and antioxidant role in erythrocytes and in hemorrhagic models in vivo. Moreover, CO is also an antioxidant by generating COHb, which protects against the pro-oxidant damaging effects of cell-free Hb. Up to now, COHb has been considered as a sink for both exogenous and endogenous CO generated during CO intoxication or heme metabolism, respectively. Hallmarking COHb as an important molecule with a biological (and eventually beneficial) role is a turning point in CO biology research, namely in CO intoxication and CO cytoprotection.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent15
dc.format.extent1352638
dc.identifier.doi10.3390/antiox12061198
dc.identifier.issn2076-3921
dc.identifier.otherPURE: 71916564
dc.identifier.otherPURE UUID: 21144751-e8a9-4663-805b-1883446af1ca
dc.identifier.otherScopus: 85163846833
dc.identifier.otherWOS: 001016892500001
dc.identifier.otherPubMed: 37371928
dc.identifier.otherPubMedCentral: PMC10294805
dc.identifier.urihttp://hdl.handle.net/10362/158007
dc.identifier.urlhttps://www.scopus.com/pages/publications/85163846833
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04378%2F2019/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0140%2F2020/PT
dc.relationInstitute for Health and Bioeconomy
dc.subjectcarbon monoxide
dc.subjectcarboxyhemoglobin
dc.subjectcytoprotection
dc.subjecthemoglobin
dc.subjectoxidative stress
dc.subjectFood Science
dc.subjectPhysiology
dc.subjectBiochemistry
dc.subjectMolecular Biology
dc.subjectClinical Biochemistry
dc.subjectCell Biology
dc.titleCarboxyhemoglobin (COHb)en
dc.title.subtitleUnavoidable Bystander or Protective Player?en
dc.typereview
degois.publication.issue6
degois.publication.titleAntioxidants
degois.publication.volume12
dspace.entity.typePublication
oaire.awardNumberLA/P/0140/2020
oaire.awardTitleInstitute for Health and Bioeconomy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0140%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication834c369e-6900-4105-aa78-6ba0e52f96ca
relation.isProjectOfPublication.latestForDiscovery834c369e-6900-4105-aa78-6ba0e52f96ca

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