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Optimizing magnetic hyperthermia for melanoma

2025-03-20Artigo científico Acesso aberto
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dc.contributor.authorSimões, Beatriz T.
dc.contributor.authorChaparro, Catarina
dc.contributor.authorVieira, Tânia
dc.contributor.authorValente, Manuel A.
dc.contributor.authorCavaco, Marco C. V.
dc.contributor.authorNeves, Vera
dc.contributor.authorSilva, Jorge C.
dc.contributor.authorBorges, João Paulo
dc.contributor.authorAlmeida, Filipe V.
dc.contributor.authorSoares, Paula
dc.contributor.institutionDCM - Departamento de Ciência dos Materiais
dc.contributor.institutionCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
dc.contributor.institutionDF – Departamento de Física
dc.contributor.pblIOP Publishing
dc.date.accessioned2025-06-12T22:09:31Z
dc.date.available2025-06-12T22:09:31Z
dc.date.issued2025-03-20
dc.descriptionFunding Information: This work was financed by FCT—Portuguese Foundation for Science and Technology, in the framework of the project PTDC/BTM-MAT/2472/2021 and projects LA/P/0037/2020, UIDP/50025/2020 and UIDB/50025/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication-i3N. C.I.P.C. is supported by the grant SFRH/BD/148588/2019 from the Portuguese Foundation for Science and Technology (FCT). Publisher Copyright: © 2025 The Author(s). Published by IOP Publishing Ltd.
dc.description.abstractSuperparamagnetic iron oxide nanoparticles (SPIONs) are widely used in magnetic hyperthermia, where their therapeutic efficacy depends on efficient heat generation. However, intracellular uptake of SPIONs has been shown to reduce their heat dissipation capacity, limiting hyperthermia performance. To address this challenge, we explored the use of small-molecule endocytosis inhibitors to block SPIONs’ uptake in vitro. SPIONs stabilized with 3-aminopropyl triethoxysilane (APTES) were evaluated in an advanced cutaneous melanoma cell line treated with a small library of endocytosis inhibitors. Among these, methyl-β-cyclodextrin significantly reduced SPIONs’ uptake compared to untreated cells. Importantly, uptake inhibition restored SPIONs’ heat dissipation capacity from specific absorption rates of 63 to 91 W g−1 and improved the temperature increase by 2.6 °C, under magnetic hyperthermia conditions. These findings demonstrate that targeting nanoparticle internalization with small-molecule inhibitors, particularly methyl-β-cyclodextrin, enhances the efficiency of magnetic hyperthermia in melanoma cells. This strategy offers a promising approach to optimize magnetic hyperthermia for melanoma treatment.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent13
dc.format.extent1364051
dc.identifier.doi10.1088/2632-959X/adbde1
dc.identifier.issn2632-959X
dc.identifier.otherPURE: 118408039
dc.identifier.otherPURE UUID: 3283b231-37f9-422f-9d50-4c8270fb0111
dc.identifier.otherScopus: 105000520124
dc.identifier.otherWOS: 001467675600001
dc.identifier.otherORCID: /0000-0001-9959-4272/work/185899703
dc.identifier.otherORCID: /0000-0002-3996-6545/work/185900511
dc.identifier.otherORCID: /0000-0001-8447-1886/work/185900805
dc.identifier.urihttp://hdl.handle.net/10362/184122
dc.identifier.urlhttps://www.scopus.com/pages/publications/105000520124
dc.identifier.urlhttps://www.webofscience.com/wos/woscc/full-record/WOS:001467675600001
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos IC&DT em Todos os Domínios Científicos/PTDC%2FBTM-MAT%2F2472%2F2021/PT
dc.relationTowards the development of a nanoparticle for early diagnosis of Alzheimer’s Disease, based on the reversible translocation of the blood brain barrier.
dc.relationInstitute of Nanostructures, Nanomodelling and Nanofabrication
dc.relationInstitute of Nanostructures, Nanomodelling and Nanofabrication
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50025%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F148588%2F2019/PT
dc.subjectIron oxide nanoparticles
dc.subjectMagnetic hyperthermia
dc.subjectMelanoma cells
dc.subjectsmall-molecule inhibitors
dc.subjectElectronic, Optical and Magnetic Materials
dc.subjectBiomaterials
dc.subjectMaterials Science (miscellaneous)
dc.subjectPolymers and Plastics
dc.titleOptimizing magnetic hyperthermia for melanomaen
dc.title.subtitlethe role of nanoparticle uptake inhibitionen
dc.typejournal article
degois.publication.firstPage1
degois.publication.issue1
degois.publication.lastPage13
degois.publication.titleNano Express
degois.publication.volume6
dspace.entity.typePublication
oaire.awardNumberPTDC/BTM-MAT/2472/2021
oaire.awardNumberLA/P/0037/2020
oaire.awardNumberUIDP/50025/2020
oaire.awardNumberUIDB/50025/2020
oaire.awardNumberSFRH/BD/148588/2019
oaire.awardTitleTowards the development of a nanoparticle for early diagnosis of Alzheimer’s Disease, based on the reversible translocation of the blood brain barrier.
oaire.awardTitleInstitute of Nanostructures, Nanomodelling and Nanofabrication
oaire.awardTitleInstitute of Nanostructures, Nanomodelling and Nanofabrication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos IC&DT em Todos os Domínios Científicos/PTDC%2FBTM-MAT%2F2472%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0037%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50025%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50025%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F148588%2F2019/PT
oaire.fundingStreamConcurso de Projetos IC&DT em Todos os Domínios Científicos
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Base
oaire.fundingStreamOE
project.funder.identifierhttp://doi.org/10.13039/501100001871
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