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The role of nutritional vitamin D in CKD-MBD in children and adults with CKD, on dialysis and after kidney transplantation - a European consensus statement

2025-04Artigo científico Acesso aberto
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dc.contributor.authorJørgensen, Hanne Skou
dc.contributor.authorVervloet, Marc
dc.contributor.authorCavalier, Etienne
dc.contributor.authorBacchetta, Justine
dc.contributor.authorde Borst, Martin H
dc.contributor.authorBover, Jordi
dc.contributor.authorCozzolino, Mario
dc.contributor.authorFerreira, Ana Carina
dc.contributor.authorHansen, Ditte
dc.contributor.authorHerrmann, Markus
dc.contributor.authorde Jongh, Renate
dc.contributor.authorMazzaferro, Sandro
dc.contributor.authorWan, Mandy
dc.contributor.authorShroff, Rukshana
dc.contributor.authorEvenepoel, Pieter
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblEuropean Renal Association - European Dialysis and Transplant Association (ERA-EDTA) | Oxford University Press
dc.date.accessioned2025-02-10T21:19:58Z
dc.date.available2025-02-10T21:19:58Z
dc.date.issued2025-04
dc.description© The Author(s) 2025. Published by Oxford University Press on behalf of the ERA.
dc.description.abstractVitamin D deficiency is common in patients with chronic kidney disease (CKD) and associates with poor outcomes. Current clinical practice guidelines recommend supplementation with nutritional vitamin D as for the general population. However, recent large-scale, clinical trials in the general population failed to demonstrate a benefit of vitamin D supplementation on skeletal or non-skeletal outcomes, fueling a debate on the rationale for screening for and correcting vitamin D deficiency, both in non-CKD and CKD populations. In a collaboration between the European Renal Osteodystrophy initiative of the European Renal Association (ERA) and the European Society for Paediatric Nephrology (ESPN), an expert panel performed an extensive literature review and formulated clinical practice points on vitamin D supplementation in children and adults with CKD and after kidney transplantation. These were reviewed by a Delphi panel of members from relevant working groups of the ERA and ESPN. Key clinical practice points include recommendations to monitor for, and correct, vitamin D deficiency in children and adults with CKD and after kidney transplantation, targeting 25-hydroxyvitamin D levels >75 nmol/L (>30 ng/mL). While vitamin D supplementation appears well-tolerated and safe, it is recommended to avoid mega-doses (≥100 000 IU) and very high levels of 25 hydroxyvitamin D (>150-200 nmol/L, or 60-80 ng/mL) to reduce the risk of toxicity. Future clinical trials should investigate the benefit of vitamin D supplementation on patient-relevant outcomes in the setting of vitamin D deficiency across different stages of CKD.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent5145900
dc.identifier.doi10.1093/ndt/gfae293
dc.identifier.issn0931-0509
dc.identifier.otherPURE: 109217438
dc.identifier.otherPURE UUID: 8eb2076d-3076-4326-827a-3f5207608139
dc.identifier.otherPubMed: 39875204
dc.identifier.otherScopus: 105001962863
dc.identifier.urihttp://hdl.handle.net/10362/178781
dc.language.isoeng
dc.peerreviewedyes
dc.subjectchronic kidney disease – mineral and bone disorder
dc.subjectkidney transplantation
dc.subjectparathyroid hormone
dc.subjectrenal osteodystrophy
dc.subjectvitamin D
dc.titleThe role of nutritional vitamin D in CKD-MBD in children and adults with CKD, on dialysis and after kidney transplantation - a European consensus statementen
dc.typejournal article
degois.publication.firstPage797
degois.publication.issue4
degois.publication.lastPage822
degois.publication.titleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
degois.publication.volume40
dspace.entity.typePublication
rcaap.rightsopenAccess

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