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Distinction and prognosis of early arthritis phenotypes

2023-11-01Artigo científico Acesso aberto
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dc.contributor.authorSepriano, Alexandre
dc.contributor.authorSepriano, Alexandre
dc.contributor.authorvan Dijk, Bastiaan
dc.contributor.authorRamiro, Sofia
dc.contributor.authorRamiro, Sofia
dc.contributor.authorvan der Helm-van Mil, Annette
dc.contributor.authorCombe, Bernard
dc.contributor.authorvan Schaardenburg, Dirkjan
dc.contributor.authorde Wit, Maarten
dc.contributor.authorKent, Alison
dc.contributor.authorMateus, Elsa
dc.contributor.authorLandewé, Robert
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBMJ Publishing Group
dc.date.accessioned2023-11-28T22:37:18Z
dc.date.available2023-11-28T22:37:18Z
dc.date.issued2023-11-01
dc.descriptionPublisher Copyright: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
dc.description.abstractOBJECTIVES: The objective of this study is to evaluate whether there are differences in the long-term prognosis across various phenotypes of early arthritis (EA). METHODS: Three EA cohorts (Reade, Etude et Suivi des Polyarthrites Indifférenciées Récentes (ESPOIR) and Early Arthritis Clinic (EAC)) were analysed. Clinical data were collected up to 24 years. Hands and feet radiographs were scored according to the Sharp van der Heijde (SvdH) method. Latent class analysis was applied to determine the EA phenotypes at baseline. Each class received a label reflecting its most prominent features. Prognostic outcomes included Health Assessment Questionnaire (HAQ), Short Form 36 (SF36) and SvdH score. The association between class membership and outcomes over time was tested in multivariable models. RESULTS: In total, 390 (Reade), 798 (ESPOIR) and 3991 (EAC) patients were analysed separately. Two classes with symmetrical polyarthritis emerged; one of these labelled as autoimmune inflammatory polyarthritis (AIPA), had high likelihood of acute phase reactants (APR) elevation and autoantibody positivity, while the other (mild-inflammatory polyarthritis; MIPA) had not. A third class had oligoarthritis of upper limbs (OAUL) and could be subdivided into autoimmune OAUL and mild-inflammatory OAUL. A fifth class had oligoarthritis of lower limbs. The SvdH scores were worse in patients with APR/autoantibodies (AIPA) than in those without (MIPA). No clinically meaningful differences across classes in HAQ or SF36 over time were found. CONCLUSION: Radiographic progression over time primarily occurs in EA patients with APR/autoantibodies. The absence of these markers, however, does not necessarily translate into better long-term function and quality of life. Clinicians should not only aim at preventing joint damage, but look beyond structural progression in order to further improve the lives of people with EA.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent554382
dc.identifier.doi10.1136/rmdopen-2023-003611
dc.identifier.issn2044-6055
dc.identifier.otherPURE: 76186590
dc.identifier.otherPURE UUID: bd04d9e8-6da1-4dab-bfec-332dfd515324
dc.identifier.otherScopus: 85175769850
dc.identifier.otherPubMed: 37914180
dc.identifier.otherWOS: 001094773800001
dc.identifier.urihttp://hdl.handle.net/10362/160664
dc.identifier.urlhttps://www.scopus.com/pages/publications/85175769850
dc.language.isoeng
dc.peerreviewedyes
dc.subjectArthritis, Rheumatoid
dc.subjectMagnetic Resonance Imaging
dc.subjectOutcome and Process Assessment, Health Care
dc.subjectRheumatology
dc.subjectImmunology and Allergy
dc.subjectImmunology
dc.titleDistinction and prognosis of early arthritis phenotypesen
dc.title.subtitlean analysis in three European cohortsen
dc.typejournal article
degois.publication.issue4
degois.publication.titleRMD Open
degois.publication.volume9
dspace.entity.typePublication
person.familyNameSepriano
person.familyNameRamiro
person.givenNameAlexandre
person.givenNameSofia
person.identifier397398
person.identifier.ciencia-id5E1B-9976-5CE4
person.identifier.ciencia-idC513-D4F1-EEC3
person.identifier.orcid0000-0003-1954-0229
person.identifier.orcid0000-0002-8899-9087
person.identifier.scopus-author-id55266526300
rcaap.rightsopenAccess
relation.isAuthorOfPublicationd87df0c7-841b-4648-a99e-296348e2e286
relation.isAuthorOfPublication9853406a-2641-440d-a8b1-a516bdb6f32f
relation.isAuthorOfPublication.latestForDiscoveryd87df0c7-841b-4648-a99e-296348e2e286

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