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Targeting Lipid Peroxidation for Cancer Treatment

2020-11-05Recensão Acesso aberto
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dc.contributor.authorClemente, Sofia M.
dc.contributor.authorMartínez-Costa, Oscar H.
dc.contributor.authorMonsalve, Maria
dc.contributor.authorSamhan-Arias, Alejandro K.
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2021-07-19T22:17:30Z
dc.date.available2021-07-19T22:17:30Z
dc.date.issued2020-11-05
dc.descriptiongrant number RTI2018-093864-B-I00
dc.description.abstractCancer is one of the highest prevalent diseases in humans. The chances of surviving cancer and its prognosis are very dependent on the affected tissue, body location, and stage at which the disease is diagnosed. Researchers and pharmaceutical companies worldwide are pursuing many attempts to look for compounds to treat this malignancy. Most of the current strategies to fight cancer implicate the use of compounds acting on DNA damage checkpoints, non-receptor tyrosine kinases activities, regulators of the hedgehog signaling pathways, and metabolic adaptations placed in cancer. In the last decade, the finding of a lipid peroxidation increase linked to 15-lipoxygenases isoform 1 (15-LOX-1) activity stimulation has been found in specific successful treatments against cancer. This discovery contrasts with the production of other lipid oxidation signatures generated by stimulation of other lipoxygenases such as 5-LOX and 12-LOX, and cyclooxygenase (COX-2) activities, which have been suggested as cancer biomarkers and which inhibitors present anti-tumoral and antiproliferative activities. These findings support the previously proposed role of lipid hydroperoxides and their metabolites as cancer cell mediators. Depletion or promotion of lipid peroxidation is generally related to a specific production source associated with a cancer stage or tissue in which cancer originates. This review highlights the potential therapeutical use of chemical derivatives to stimulate or block specific cellular routes to generate lipid hydroperoxides to treat this disease.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2051643
dc.identifier.doi10.3390/molecules25215144
dc.identifier.issn1420-3049
dc.identifier.otherPURE: 28536792
dc.identifier.otherPURE UUID: 20b0b5ce-621e-4596-9f3c-e25918044f0f
dc.identifier.otherScopus: 85095961719
dc.identifier.otherPubMed: 33167334
dc.identifier.otherPubMedCentral: PMC7663840
dc.identifier.otherWOS: 000589380900001
dc.identifier.urihttp://hdl.handle.net/10362/121294
dc.identifier.urlhttps://www.scopus.com/pages/publications/85095961719
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/721236/EU
dc.relationTraining European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia
dc.subjectcancer
dc.subjectCOX
dc.subjectFenton reaction
dc.subjectferroptosis
dc.subjectiron
dc.subjectLOX
dc.subjectnanoparticles
dc.subjectperoxides
dc.subjectAnalytical Chemistry
dc.subjectChemistry (miscellaneous)
dc.subjectMolecular Medicine
dc.subjectPharmaceutical Science
dc.subjectDrug Discovery
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectSDG 3 - Good Health and Well-being
dc.titleTargeting Lipid Peroxidation for Cancer Treatmenten
dc.typereview
degois.publication.issue21
degois.publication.titleMolecules
degois.publication.volume25
dspace.entity.typePublication
oaire.awardNumber721236
oaire.awardTitleTraining European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/721236/EU
oaire.fundingStreamH2020
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccess
relation.isProjectOfPublicationa1b35958-08bf-49b3-aad9-cb7f9db79976
relation.isProjectOfPublication.latestForDiscoverya1b35958-08bf-49b3-aad9-cb7f9db79976

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