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Portuguese recommendations for the use of methotrexate in rheumatic diseases - 2016 update

2018-02Artigo científico Acesso aberto
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dc.contributor.authorDuarte, Ana Catarina
dc.contributor.authorSantos-Faria, D.
dc.contributor.authorGonçalves, M. J.
dc.contributor.authorSepriano, A.
dc.contributor.authorSepriano, Alexandre
dc.contributor.authorMourão, A. F.
dc.contributor.authorDuarte, C.
dc.contributor.authorNeves, J. S.
dc.contributor.authorÁgueda, A. F.
dc.contributor.authorRibeiro, P. A.
dc.contributor.authorDaniel, A.
dc.contributor.authorNeto, A.
dc.contributor.authorCordeiro, Ana Cristina
dc.contributor.authorRodrigues, A.
dc.contributor.authorBarcelos, A.
dc.contributor.authorSilva, C.
dc.contributor.authorPonte, C.
dc.contributor.authorVieira-Sousa, E.
dc.contributor.authorTeixeira, F.
dc.contributor.authorOliveira-Ramos, F.
dc.contributor.authorAraújo, F.
dc.contributor.authorBarcelos, F.
dc.contributor.authorCanhão, H.
dc.contributor.authorCanhão, Helena
dc.contributor.authorSantos, H.
dc.contributor.authorRamos, J.
dc.contributor.authorPolido-Pereira, J.
dc.contributor.authorTavares-Costa, J.
dc.contributor.authorMelo Gomes, J. A.
dc.contributor.authorCunha-Miranda, L.
dc.contributor.authorCosta, L.
dc.contributor.authorCerqueira, M.
dc.contributor.authorCruz, M.
dc.contributor.authorSantos, M. J.
dc.contributor.authorBernardes, M.
dc.contributor.authorOliveira, P.
dc.contributor.authorAbreu, P.
dc.contributor.authorFigueira, R.
dc.contributor.authorBarros, R.
dc.contributor.authorFalcão, S.
dc.contributor.authorPinto, P.
dc.contributor.authorPimenta, S.
dc.contributor.authorCapela, S.
dc.contributor.authorTeixeira, V.
dc.contributor.authorFonseca, J. E.
dc.contributor.authorSociedade Portuguesa de Reumatologia (SPR)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblSociedade Portuguesa de Reumatologia
dc.date.accessioned2018-03-15T23:18:54Z
dc.date.available2018-03-15T23:18:54Z
dc.date.issued2018-02
dc.description.abstractBackground: Methotrexate (MTX) is the first-line drug in the treatment of rheumatoid arthritis (RA) and the most commonly prescribed disease modifying antirheumatic drug. Moreover, it is also used as an adjuvant drug in patients under biologic therapies, enhancing the efficacy of biologic agents. Objectives: To review the literature and update the Portuguese recommendations for the use of MTX in rheumatic diseases first published in 2009. Methods: The first Portuguese guidelines for the use of MTX in rheumatic diseases were published in 2009 and were integrated in the multinational 3E Initiative (Evi - dence Expertise Exchange) project. The Portuguese rheumatologists based on literature evidence and consensus opinion formulated 13 recommendations. At a national meeting, the recommendations included in this document were further discussed and updated. The document resulting from this meeting circulated to all Portuguese rheumatologists, who anonymously voted online on the level of agreement with the updated recommendations. Results: Results presented in this article are mainly in accordance with previous guidelines, with some new information regarding hepatitis B infection during MTX treatment, pulmonary toxicity monitoring, hepatotoxi - city management, association with hematologic neoplasms, combination therapy and tuberculosis scree - ning during treatment. Conclusion: The present recommendations combine scientific evidence with expert opinion and attained desirable agreement among Portuguese rheumatologists. The regular update of these recommendations is essen - tial in order to keep them a valid and useful tool in daily practice.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent14
dc.format.extent306071
dc.identifier.issn0303-464X
dc.identifier.otherPURE: 3694262
dc.identifier.otherPURE UUID: f7c3c8af-1cfe-4aa6-a2e0-281835c9ed96
dc.identifier.otherScopus: 85042561287
dc.identifier.otherWOS: 000428132400011
dc.identifier.otherORCID: /0000-0003-1894-4870/work/67178179
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=85042561287&partnerID=8YFLogxK
dc.identifier.urihttp://www.actareumatologica.pt/archive_detail.php?id=217
dc.identifier.urlhttps://www.scopus.com/pages/publications/85042561287
dc.identifier.urlhttp://www.actareumatologica.pt/archive_detail.php?id=217
dc.language.isoeng
dc.peerreviewedyes
dc.subjectMethotrexate
dc.subjectPortugal
dc.subjectRecommendations
dc.subjectRheumatic diseases
dc.subjectRheumatoid arthritis
dc.subjectRheumatology
dc.subjectSDG 3 - Good Health and Well-being
dc.titlePortuguese recommendations for the use of methotrexate in rheumatic diseases - 2016 updateen
dc.typejournal article
degois.publication.firstPage91
degois.publication.issue1
degois.publication.lastPage104
degois.publication.titleActa Reumatológica Portuguesa
degois.publication.volume2018
dspace.entity.typePublication
person.familyNameSepriano
person.familyNameCanhão
person.givenNameAlexandre
person.givenNameHelena
person.identifier397398
person.identifier379800
person.identifier.ciencia-id5E1B-9976-5CE4
person.identifier.ciencia-id5A17-C6D9-DBC8
person.identifier.orcid0000-0003-1954-0229
person.identifier.orcid0000-0003-1894-4870
person.identifier.ridC-9611-2018
person.identifier.scopus-author-id55266526300
person.identifier.scopus-author-id6602393492
rcaap.rightsopenAccess
relation.isAuthorOfPublicationd87df0c7-841b-4648-a99e-296348e2e286
relation.isAuthorOfPublicationc87f58c0-b53d-4321-9bd7-39554e6001b5
relation.isAuthorOfPublication.latestForDiscoveryc87f58c0-b53d-4321-9bd7-39554e6001b5

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