Synthesis of Bis(3-indolyl)methanes Mediated by Potassium tert-Butoxide

Santos, A. Sofia; Ferro, Rita D.; Viduedo, Nuno; Maia, Luísa B.; Silva, Artur M. S.; Marques, M. Manuel B.

http://hdl.handle.net/10362/150333

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Autores

Marques, M. Manuel B.

Resumo(s)

The indole moiety is an important N-heterocycle found in natural products, and a key structural component of many value-added chemicals including pharmaceuticals. In particular, bis(3-indolyl)methanes (BIMs) are an important subgroup of indoles, composed of two indole units. Herein, we report the development of a simple method to access BIMs derivatives in yields of up to 77 % by exploiting a tBuOK-mediated coupling reaction of indoles and benzyl alcohols.

Descrição

The National NMR Facility is supported by FCT, ROTEIRO/0031/2013-PINFRA/22161/2016, co-financed by FEDER through COMPETE2020, POCI, and PORLandFCT through PIDDAC) and CERMAX(022162).