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Cell division and chromosome segregation in Staphylococcus aureus
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Bacterial cell division by binary fission involves several essential steps. Initially,
the mother cell duplicates in size and replicates its DNA, in preparation for division. As the
new sister chromosomes are synthesized, they are progressively segregated to the future
daughter cells and once the division site is cleared of the majority of chromosomal DNA,
the division septum starts assembling. The complete septum then constricts and,
ultimately, the mother cell splits into two identical daughters. The generation of equal,
viable progeny is strictly dependent on the regulation and coordination of these
processes, both in space and in time. It is particularly important that the division septum
is properly positioned at midcell and that chromosome segregation and cell division are
synchronized, to prevent fragmentation of the genome by septum closure over the
nucleoid.
Descrição
Dissertação para a obtenção do grau de doutor em Biologia pelo Instituto de Tecnologia Química e Biológica. Universidade Nova de Lisboa
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica