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Effects of vitamin D levels during pregnancy on prematurity

2024-02-28Artigo científico Acesso aberto
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dc.contributor.authorBarbosa, Olívia
dc.contributor.authorSim-Sim, Margarida
dc.contributor.authorSilvestre, Marta Pereira
dc.contributor.authorPedro, Cristina
dc.contributor.authorCruz, Dulce
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBMJ Publishing Group
dc.date.accessioned2024-04-11T00:36:21Z
dc.date.available2024-04-11T00:36:21Z
dc.date.issued2024-02-28
dc.description© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
dc.description.abstractINTRODUCTION: Prematurity is an urgent public health problem worldwide. Recent studies associate maternal hypovitaminosis D during pregnancy with an increased risk of prematurity. However, the evidence on this association remains inconclusive, and there is lack of consensus in the literature. The exact mechanism by which low vitamin D levels may increase the risk of preterm birth is not yet fully understood. Nevertheless, it is known that vitamin D may play a role in maintaining a healthy pregnancy by regulating inflammation and immunomodulation by acting on the maternal and fetal immune systems. Inflammation and immune dysregulation are both associated with preterm birth, and low vitamin D levels may exacerbate these processes. The results of this review may have important implications for clinical practice and public health policy, particularly regarding vitamin D supplementation during pregnancy. METHODS AND ANALYSIS: A systematic review of the literature will be conducted. The search will be performed in electronic databases: CINAHL; MEDLINE; Cochrane Central Register of Controlled Trials; Cochrane Library; Academic Search Complete; Information Science and Technology Abstracts; MedicLatina; SCOPUS; PubMed; and Google Scholar, with the chronological range of January 2018 to November 2022. The search strategy will include the following Medical Subject Headings or similar terms: 'Vitamin D'; '25-hydroxyvitamin D'; 'Hypovitaminosis D'; 'Pregnancy'; 'Pregnant women'; 'Expectant mother'; 'Prematurity'; 'Premature birth'; 'Premature delivery'; 'Preterm birth'; and 'Preterm labour'. This review will include quantitative primary studies, both experimental (clinical trials) and observational (cohort, cross-sectional, and case-control). The quality of each selected study and the results obtained will be assessed by two reviewers separately, using the Cochrane risk of bias tool for evaluating randomised clinical trials or the Newcastle Ottawa Scale for non-randomised studies, following the respective checklist. In case of disagreement, a third reviewer will be consulted. ETHICS AND DISSEMINATION: This study does not involve human subjects and therefore does not require ethics approval. The results will be disseminated through publication in a peer-reviewed scientific journal and through conference presentations. All changes made to the protocol will be registered in PROSPERO, with information on the nature and justification for the changes made. PROSPERO REGISTRATION NUMBER: CRD42022303901.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent256920
dc.identifier.doi10.1136/bmjopen-2023-076702
dc.identifier.issn2044-6055
dc.identifier.otherPURE: 87133613
dc.identifier.otherPURE UUID: e0aeeaa4-32da-41dd-acdc-c9d23de1a96a
dc.identifier.otherPubMed: 38418231
dc.identifier.otherPubMedCentral: PMC10910675
dc.identifier.otherORCID: /0000-0001-9327-2897/work/157393175
dc.identifier.otherScopus: 85186391773
dc.identifier.urihttp://hdl.handle.net/10362/166081
dc.language.isoeng
dc.peerreviewedyes
dc.subjectPregnancy
dc.subjectFemale
dc.subjectInfant, Newborn
dc.subjectHumans
dc.subjectPremature Birth
dc.subjectCross-Sectional Studies
dc.subjectSystematic Reviews as Topic
dc.subjectVitamins/therapeutic use
dc.subjectVitamin D/pharmacology
dc.subjectVitamin D Deficiency/complications
dc.subjectInfant, Newborn, Diseases
dc.subjectInflammation
dc.subjectReview Literature as Topic
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEffects of vitamin D levels during pregnancy on prematurityen
dc.title.subtitlea systematic review protocolen
dc.typejournal article
degois.publication.issue2
degois.publication.titleBMJ Open
degois.publication.volume14
dspace.entity.typePublication
rcaap.rightsopenAccess

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