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The Potential Modulatory Effects of Exercise on Skeletal Muscle Redox Status in Chronic Kidney Disease

2023-04Recensão Acesso aberto
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dc.contributor.authorMendes, Sara
dc.contributor.authorLeal, Diogo V.
dc.contributor.authorBaker, Luke A.
dc.contributor.authorFerreira, Aníbal
dc.contributor.authorSmith, Alice C.
dc.contributor.authorViana, João L.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2023-04-26T22:20:57Z
dc.date.available2023-04-26T22:20:57Z
dc.date.issued2023-04
dc.descriptionFunding Information: SM is supported by a Portuguese Foundation of Science and Technology (FCT) doctoral grant (SFRH/BD/07740/2020). The Research Center in Sports Sciences, Health Sciences and Human Development is funded by FCT (UID/04045/2020). Publisher Copyright: © 2023 by the authors.
dc.description.abstractChronic Kidney Disease (CKD) is a global health burden with high mortality and health costs. CKD patients exhibit lower cardiorespiratory and muscular fitness, strongly associated with morbidity/mortality, which is exacerbated when they reach the need for renal replacement therapies (RRT). Muscle wasting in CKD has been associated with an inflammatory/oxidative status affecting the resident cells’ microenvironment, decreasing repair capacity and leading to atrophy. Exercise may help counteracting such effects; however, the molecular mechanisms remain uncertain. Thus, trying to pinpoint and understand these mechanisms is of particular interest. This review will start with a general background about myogenesis, followed by an overview of the impact of redox imbalance as a mechanism of muscle wasting in CKD, with focus on the modulatory effect of exercise on the skeletal muscle microenvironment.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2115740
dc.identifier.doi10.3390/ijms24076017
dc.identifier.issn1661-6596
dc.identifier.otherPURE: 59389374
dc.identifier.otherPURE UUID: 1f83e67f-0097-488b-9cb5-7b5b463ab58f
dc.identifier.otherScopus: 85152304769
dc.identifier.otherPubMed: 37046990
dc.identifier.otherWOS: 000970345900001
dc.identifier.urihttp://hdl.handle.net/10362/152169
dc.identifier.urlhttps://www.scopus.com/pages/publications/85152304769
dc.language.isoeng
dc.peerreviewedyes
dc.subjectchronic kidney disease
dc.subjectexercise
dc.subjectoxidative stress
dc.subjectreactive oxygen species (ROS)
dc.subjectskeletal muscle wasting
dc.subjectCatalysis
dc.subjectMolecular Biology
dc.subjectSpectroscopy
dc.subjectComputer Science Applications
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectInorganic Chemistry
dc.titleThe Potential Modulatory Effects of Exercise on Skeletal Muscle Redox Status in Chronic Kidney Diseaseen
dc.typereview
degois.publication.issue7
degois.publication.titleInternational Journal of Molecular Sciences
degois.publication.volume24
dspace.entity.typePublication
rcaap.rightsopenAccess

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