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Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm

2023-10Artigo científico Acesso aberto
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dc.contributor.authorBouwens, Elke
dc.contributor.authorVanmaele, Alexander
dc.contributor.authorHoeks, Sanne E.
dc.contributor.authorVerhagen, Hence J.M.
dc.contributor.authorFioole, Bram
dc.contributor.authorMoelker, Adriaan
dc.contributor.authorten Raa, Sander
dc.contributor.authorHussain, Burhan
dc.contributor.authorOliveira-Pinto, José
dc.contributor.authorBastos Gonçalves, Frederico
dc.contributor.authorIjpma, Arne S.
dc.contributor.authorHoefer, Imo E.
dc.contributor.authorvan Lier, Felix
dc.contributor.authorAkkerhuis, K. Martijn
dc.contributor.authorMajoor-Krakauer, Danielle F.
dc.contributor.authorBoersma, Eric
dc.contributor.authorKardys, Isabella
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblSAGE Publications
dc.date.accessioned2023-07-18T22:15:58Z
dc.date.available2023-07-18T22:15:58Z
dc.date.issued2023-10
dc.descriptionFunding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work is supported by Stichting Lijf en Leven. The sponsor had no role in study design, methods, subject recruitment, data collection or analysis, or preparation of the manuscript. Publisher Copyright: © The Author(s) 2023.
dc.description.abstractBackground: Surveillance programs in abdominal aortic aneurysms (AAA) are mainly based on imaging and leave room for improvement to timely identify patients at risk for AAA growth. Many biomarkers are dysregulated in patients with AAA, which fuels interest in biomarkers as indicators of disease progression. We examined associations of 92 cardiovascular disease (CVD)-related circulating biomarkers with AAA and sac volume. Methods: In a cross-sectional analysis, we separately investigated (1) 110 watchful waiting (WW) patients (undergoing periodic surveillance imaging without planned intervention) and (2) 203 patients after endovascular aneurysm repair (EVAR). The Cardiovascular Panel III (Olink Proteomics AB, Sweden) was used to measure 92 CVD-related circulating biomarkers. We used cluster analyses to investigate protein-based subphenotypes, and linear regression to examine associations of biomarkers with AAA and sac volume on CT scans. Results: Cluster analyses revealed two biomarker-based subgroups in both WW and EVAR patients, with higher levels of 76 and 74 proteins, respectively, in one subgroup versus the other. In WW patients, uPA showed a borderline significant association with AAA volume. Adjusting for clinical characteristics, there was a difference of −0.092 (−0.148, −0.036) loge mL in AAA volume per SD uPA. In EVAR patients, after multivariable adjustment, four biomarkers remained significantly associated with sac volume. The mean effects on sac volume per SD difference were: LDLR: −0.128 (−0.212, −0.044), TFPI: 0.139 (0.049, 0.229), TIMP4: 0.110 (0.023, 0.197), IGFBP-2: 0.103 (0.012, 0.194). Conclusion: LDLR, TFPI, TIMP4, and IGFBP-2 were independently associated with sac volume after EVAR. Subgroups of patients with high levels of the majority of CVD-related biomarkers emphasize the intertwined relationship between AAA and CVD. ClinicalTrials.gov Identifier: NCT03703947.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent268675
dc.identifier.doi10.1177/1358863X231181159
dc.identifier.issn1358-863X
dc.identifier.otherPURE: 66651136
dc.identifier.otherPURE UUID: da0e9375-4be1-43d5-ad4e-ac6618222650
dc.identifier.otherScopus: 85164208122
dc.identifier.otherPubMed: 37395286
dc.identifier.otherORCID: /0000-0002-9825-9007/work/151413399
dc.identifier.urihttp://hdl.handle.net/10362/155490
dc.identifier.urlhttps://www.scopus.com/pages/publications/85164208122
dc.language.isoeng
dc.peerreviewedyes
dc.subjectabdominal aortic aneurysm (AAA)
dc.subjectbiomarkers
dc.subjectcardiovascular diseases
dc.subjectendovascular aneurysm repair
dc.subjectCardiology and Cardiovascular Medicine
dc.subjectSDG 3 - Good Health and Well-being
dc.titleCirculating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysmen
dc.typejournal article
degois.publication.firstPage433
degois.publication.issue5
degois.publication.lastPage442
degois.publication.titleVascular Medicine (United Kingdom)
degois.publication.volume28
dspace.entity.typePublication
rcaap.rightsopenAccess

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