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The use of effect biomarkers in chemical mixtures risk assessment

2024-05-01Artigo científico Acesso aberto
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dc.contributor.authorLadeira, Carina
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - Pólo ENSP
dc.contributor.institutionCentro de Investigação em Saúde Pública (CISP/PHRC)
dc.contributor.pblElsevier
dc.date.accessioned2024-06-13T00:33:29Z
dc.date.available2024-06-13T00:33:29Z
dc.date.issued2024-05-01
dc.descriptionFunding Information: The author thanks to H&TRC- Health & Technology Research Center- Escola Superior de Tecnologia da Sa\u00FAde, Instituto Polit\u00E9cnico de Lisboa; FCT/MCTES national support through the UIDP/05608/2020 (https://doi.org/10.54499/UIDP/05608/2020), UIDB/05608/2020 (https://doi.org/10.54499/UIDB/05608/2020) and, IPL/2021/PLASCOGEN_ESTeSL. Publisher Copyright: © 2024 The Authors
dc.description.abstractHuman epidemiological studies with biomarkers of effect play an invaluable role in identifying health effects with chemical exposures and in disease prevention. Effect biomarkers that measure genetic damage are potent tools to address the carcinogenic and/or mutagenic potential of chemical exposures, increasing confidence in regulatory risk assessment decision-making processes. The micronucleus (MN) test is recognized as one of the most successful and reliable assays to assess genotoxic events, which are associated with exposures that may cause cancer. To move towards the next generation risk assessment is crucial to establish bridges between standard approaches, new approach methodologies (NAMs) and tools for increase the mechanistically-based biological plausibility in human studies, such as the adverse outcome pathways (AOPs) framework. This paper aims to highlight the still active role of MN as biomarker of effect in the evolution and applicability of new methods and approaches in human risk assessment, with the positive consequence, that the new methods provide a deeper knowledge of the mechanistically-based biology of these endpoints.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1412251
dc.identifier.doi10.1016/j.mrgentox.2024.503768
dc.identifier.issn1383-5718
dc.identifier.otherPURE: 93237677
dc.identifier.otherPURE UUID: 07891033-dd9d-4109-a838-78523f2b16c0
dc.identifier.otherScopus: 85193435168
dc.identifier.otherPubMed: 38821670
dc.identifier.otherWOS: 001244219100001
dc.identifier.urihttp://hdl.handle.net/10362/168506
dc.identifier.urlhttps://www.scopus.com/pages/publications/85193435168
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAdverse outcome pathways
dc.subjectChemical mixtures
dc.subjectGenotoxicity
dc.subjectHuman risk assessment
dc.subjectMicronucleus
dc.subjectNew approach methodologies
dc.subjectGenetics
dc.subjectHealth, Toxicology and Mutagenesis
dc.subjectSDG 3 - Good Health and Well-being
dc.titleThe use of effect biomarkers in chemical mixtures risk assessmenten
dc.title.subtitleare they still important?en
dc.typejournal article
degois.publication.titleMutation Research - Genetic Toxicology and Environmental Mutagenesis
degois.publication.volume896
dspace.entity.typePublication
rcaap.rightsopenAccess

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