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Chitin-Glucan Complex Hydrogels: Optimization of Gel Formation and Demonstration of Drug Loading and Release Ability

2022-02-17Artigo científico Acesso aberto
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dc.contributor.authorAraújo, Diana
dc.contributor.authorRodrigues, Thomas
dc.contributor.authorAlves, Vítor D.
dc.contributor.authorFreitas, Filomena
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2022-03-09T23:25:17Z
dc.date.available2022-03-09T23:25:17Z
dc.date.issued2022-02-17
dc.descriptionLA/P/0140/202019 SFRH/BD/140829/2018
dc.description.abstractChitin-glucan complex (CGC) hydrogels were fabricated through a freeze–thaw procedure for biopolymer dissolution in NaOH 5 mol/L, followed by a dialysis step to promote gelation. Compared to a previously reported methodology that included four freeze–thaw cycles, reducing the number of cycles to one had no significant impact on the hydrogels’ formation, as well as reducing the total freezing time from 48 to 18 h. The optimized CGC hydrogels exhibited a high and nearly spontaneous swelling ratio (2528 ± 68%) and a water retention capacity of 55 ± 3%, after 2 h incubation in water, at 37◦C. Upon loading with caffeine as a model drug, an enhancement of the mechanical and rheological properties of the hydrogels was achieved. In particular, the compressive modulus was improved from 23.0 ± 0.89 to 120.0 ± 61.64 kPa and the storage modulus increased from 149.9 ± 9.8 to 315.0 ± 76.7 kPa. Although the release profile of caffeine was similar in PBS and NaCl 0.9% solutions, the release rate was influenced by the solutions’ pH and ionic strength, being faster in the NaCl solution. These results highlight the potential of CGC based hydrogels as promising structures to be used as drug delivery devices in biomedical applications.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent3527260
dc.identifier.doi10.3390/polym14040785
dc.identifier.otherPURE: 42215833
dc.identifier.otherPURE UUID: 122817b0-8bda-4034-b787-c77bfeecffee
dc.identifier.otherScopus: 85125205469
dc.identifier.otherPubMed: 35215701
dc.identifier.otherPubMedCentral: PMC8877193
dc.identifier.otherORCID: /0000-0002-9430-4640/work/109596599
dc.identifier.otherWOS: 000762692500001
dc.identifier.urihttp://hdl.handle.net/10362/134196
dc.identifier.urlhttps://www.scopus.com/pages/publications/85125205469
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationLinking Landscape, Environment, Agriculture and Food
dc.relationLinking Landscape, Environment, Agriculture and Food
dc.relationTransdermal delivery systems based on natural polymeric biomaterials
dc.relationinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F140829%2F2018/PT
dc.subjectGeneral Chemistry
dc.subjectPolymers and Plastics
dc.titleChitin-Glucan Complex Hydrogels: Optimization of Gel Formation and Demonstration of Drug Loading and Release Abilityen
dc.typejournal article
degois.publication.issue4
degois.publication.titlePolymers
degois.publication.volume14
dspace.entity.typePublication
oaire.awardNumberUIDP/04378/2020
oaire.awardNumberUIDB/04378/2020
oaire.awardNumberUIDP/04129/2020
oaire.awardNumberUIDB/04129/2020
oaire.awardNumberSFRH/BD/140829/2018
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleLinking Landscape, Environment, Agriculture and Food
oaire.awardTitleLinking Landscape, Environment, Agriculture and Food
oaire.awardTitleTransdermal delivery systems based on natural polymeric biomaterials
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04129%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04129%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F140829%2F2018/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
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