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Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery

2017-02-01Artigo científico Acesso aberto
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dc.contributor.authorMarques, Joana
dc.contributor.authorValle-Delgado, Juan José
dc.contributor.authorUrbán, Patricia
dc.contributor.authorBaró, Elisabet
dc.contributor.authorProhens, Rafel
dc.contributor.authorMayor, Alfredo
dc.contributor.authorCisteró, Pau
dc.contributor.authorDelves, Michael
dc.contributor.authorSinden, Robert E.
dc.contributor.authorGrandfils, Christian
dc.contributor.authorde Paz, José L.
dc.contributor.authorGarcía-Salcedo, José A.
dc.contributor.authorFernàndez-Busquets, Xavier
dc.contributor.institutionVector borne diseases and pathogens (VBD)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.pblFuture Medicine
dc.date.accessioned2018-05-24T22:05:57Z
dc.date.available2018-05-24T22:05:57Z
dc.date.issued2017-02-01
dc.description.abstractThe adaptation of existing antimalarial nanocarriers to new Plasmodium stages, drugs, targeting molecules, or encapsulating structures is a strategy that can provide new nanotechnology-based, cost-efficient therapies against malaria. We have explored the modification of different liposome prototypes that had been developed in our group for the targeted delivery of antimalarial drugs to Plasmodium-infected red blood cells (pRBCs). These new models include: (i) immunoliposome-mediated release of new lipid-based antimalarials; (ii) liposomes targeted to pRBCs with covalently linked heparin to reduce anticoagulation risks; (iii) adaptation of heparin to pRBC targeting of chitosan nanoparticles; (iv) use of heparin for the targeting of Plasmodium stages in the mosquito vector; and (v) use of the non-anticoagulant glycosaminoglycan chondroitin 4-sulfate as a heparin surrogate for pRBC targeting. The results presented indicate that the tuning of existing nanovessels to new malaria-related targets is a valid low-cost alternative to the de novo development of targeted nanosystems.en
dc.description.versionpreprint
dc.description.versionpublished
dc.format.extent11
dc.format.extent1296147
dc.identifier.doi10.1016/j.nano.2016.09.010
dc.identifier.issn1549-9634
dc.identifier.otherPURE: 3281908
dc.identifier.otherPURE UUID: d102000b-f41d-4003-8e65-a55be04a880a
dc.identifier.otherScopus: 85009876187
dc.identifier.otherPubMed: 27720930
dc.identifier.otherORCID: /0000-0003-1827-2912/work/68960819
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=85009876187&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/85009876187
dc.language.isoeng
dc.peerreviewedyes
dc.subjectGlycosaminoglycans
dc.subjectMalaria
dc.subjectNanomedicine
dc.subjectPlasmodium
dc.subjectTargeted drug delivery
dc.subjectBioengineering
dc.subjectMedicine (miscellaneous)
dc.subjectMolecular Medicine
dc.subjectBiomedical Engineering
dc.subjectGeneral Materials Science
dc.subjectPharmaceutical Science
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAdaptation of targeted nanocarriers to changing requirements in antimalarial drug deliveryen
dc.typejournal article
degois.publication.firstPage515
degois.publication.issue2
degois.publication.lastPage525
degois.publication.titleNanomedicine: Nanotechnology, Biology, and Medicine
degois.publication.volume13
dspace.entity.typePublication
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