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Pooling Saliva Sample as an Effective Strategy for the Systematic CMV Screening of Newborns-A Multicentric Prospective Study

2023-12-01Artigo científico Acesso aberto
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dc.contributor.authorChasqueira, Maria-Jesus
dc.contributor.authorChasqueira, Maria-Jesus
dc.contributor.authorFernandez, Catarina
dc.contributor.authorMarques, Augusta
dc.contributor.authorRodrigues, Lucia
dc.contributor.authorMarçal, Mónica
dc.contributor.authorTuna, Madalena
dc.contributor.authorBraz, Monica
dc.contributor.authorS Neto, Ana
dc.contributor.authorMendes, Candida
dc.contributor.authorLito, David
dc.contributor.authorVasconcellos, Gabriela
dc.contributor.authorRocha, Paula
dc.contributor.authorCassiano, Gonçalo
dc.contributor.authorSilva, Pedro
dc.contributor.authorMonteiro, Luísa
dc.contributor.authorSequeira, Ana
dc.contributor.authorFavila Menezes, Maria
dc.contributor.authorAlbuquerque, Margarida
dc.contributor.authorRego de Sousa, Maria José
dc.contributor.authorPaixão, Paulo
dc.contributor.authorPaixão, Paulo
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblWilliams & Wilkins
dc.date.accessioned2023-11-17T22:11:26Z
dc.date.available2023-11-17T22:11:26Z
dc.date.issued2023-12-01
dc.description.abstractBACKGROUND: Cytomegalovirus is the most common cause of congenital infections worldwide. Screening all newborns in the first 2 weeks of life is the only way to detect all cases of congenital infection, allowing the monitoring of children with asymptomatic infection at birth and early intervention. AIM: In this multicenter study, we aimed to evaluate the feasibility of using a saliva pool strategy for mass screening in 7 Portuguese hospitals, and to estimate the current prevalence of this congenital infection in these hospitals. METHODS: A total of 7033 newborns were screened between June 2020 and June 2022, and 704 pools of 10 saliva samples were analyzed by polymerase chain reaction (PCR). RESULTS: Of the 704 pools analyzed, 685 were negative and 19 had positive PCR results for cytomegalovirus. After individual PCR testing, 26 newborns had positive saliva results, of which 15 were confirmed by urine testing. Thus, this study's prevalence of congenital infection was 0.21% (95% confidence interval: 0.12%-0.35%). CONCLUSIONS: In this study, the pooling strategy proved to be effective for the systematic screening of newborns, although this low prevalence raises questions regarding the cost-effectiveness of implementing universal screening. However, this prevalence is probably the result of the control measures taken during the pandemic; therefore, the rates are expected to return to prepandemic values, but only a new study after the pandemic will be able to confirm this.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent392119
dc.identifier.doi10.1097/INF.0000000000004096
dc.identifier.issn0891-3668
dc.identifier.otherPURE: 74232735
dc.identifier.otherPURE UUID: 98af3a2e-024d-4cb1-96a0-bd12762d02c9
dc.identifier.otherPubMed: 37725820
dc.identifier.otherScopus: 85178500661
dc.identifier.urihttp://hdl.handle.net/10362/160095
dc.language.isoeng
dc.peerreviewedyes
dc.subjectCMV
dc.subjectcongenital
dc.subjectscreening
dc.subjectpool
dc.titlePooling Saliva Sample as an Effective Strategy for the Systematic CMV Screening of Newborns-A Multicentric Prospective Studyen
dc.typejournal article
degois.publication.firstPage1117
degois.publication.issue12
degois.publication.lastPage1120
degois.publication.titleThe Pediatric infectious disease journal
degois.publication.volume42
dspace.entity.typePublication
person.familyNameChasqueira
person.familyNamePaixão
person.givenNameMaria-Jesus
person.givenNamePaulo
person.identifier.orcid0000-0002-8015-7109
person.identifier.orcid0000-0002-4294-0872
person.identifier.scopus-author-id6508103792
rcaap.rightsopenAccess
relation.isAuthorOfPublication072ec2a7-7dea-429d-bdb3-2d9fa3f1e79d
relation.isAuthorOfPublication05b765bd-f025-43ee-8cf5-2e54ceb007cb
relation.isAuthorOfPublication.latestForDiscovery05b765bd-f025-43ee-8cf5-2e54ceb007cb

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