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Phytosomes with persimmon (Diospyros kaki l.) extract

2019-06-01Artigo científico Acesso aberto
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dc.contributor.authorDireito, Rosa
dc.contributor.authorReis, Catarina
dc.contributor.authorRoque, Luís
dc.contributor.authorGonçalves, Margarida
dc.contributor.authorSanches-Silva, Ana
dc.contributor.authorGaspar, Maria Manuela
dc.contributor.authorPinto, Rui
dc.contributor.authorRocha, João
dc.contributor.authorSepodes, Bruno
dc.contributor.authorBronze, Maria Rosário
dc.contributor.authorFigueira, Maria Eduardo
dc.contributor.institutionMEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de Recursos
dc.contributor.institutionDCTB - Departamento de Ciências e Tecnologia da Biomassa (ex-GDEH)
dc.contributor.institutionInstituto de Tecnologia Química e Biológica António Xavier (ITQB)
dc.contributor.pblACS - American Chemical Society
dc.date.accessioned2023-01-04T22:14:02Z
dc.date.available2023-01-04T22:14:02Z
dc.date.issued2019-06-01
dc.descriptionThis research was funded by Universidade de Lisboa PhD grant: REITORIA/BD/FF01/2015. supported in part through Grant UID/DTP/04138/2019 from Fundação para a Ciência e a Tecnologia (FCT), Portugal.
dc.description.abstractPersimmon (Diospyros kaki L.), a fruit rich in phenolic compounds (PCs), has been considered effective in mitigating oxidative damage induced by an excess of reactive oxygen species. Due to large molecular weight and intrinsic instability in some physiological fluids, PCs’ passage through biological membranes is very limited. Carriers like phytosomes are promising systems to optimize oral absorption of encapsulated extracts. This work prepared and fully characterized phytosomes containing bioactive phenolic extracts from persimmon in terms of size, surface charge, encapsulation efficiency and stability over six months. These phytosomes were orally dosed to Wistar rats during a 15-day period. Afterwards, haematological and biochemical analyses were performed. Monodisperse phytosomes were successfully prepared, with size less than 300nm (PI < 0.3) and high encapsulation efficiency (97.4%) of PCs. In contrast to free extract, extract-loaded phytosomes had higher antioxidant activity after 6 months storage. Oral administration of extract-loaded phytosomes and free extract did not lead to lipidic profile changes and were within referenced normal ranges, as well as glycaemia levels and urine parameters. The results highlighted the potential of persimmon PCs as food supplements or pharmacological tools, suggesting a promising and safe phytosomal formulation containing bioactive agents of persimmon that could lead to health benefits.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1519131
dc.identifier.doi10.3390/pharmaceutics11060296
dc.identifier.issn1543-8384
dc.identifier.otherPURE: 16600908
dc.identifier.otherPURE UUID: 4e59b612-266a-4c29-a77d-40adf2c8facd
dc.identifier.otherScopus: 85069871346
dc.identifier.otherPubMed: 31234548
dc.identifier.otherPubMedCentral: PMC6630258
dc.identifier.otherWOS: 000475330500048
dc.identifier.otherORCID: /0000-0002-0940-519X/work/73354829
dc.identifier.urihttp://hdl.handle.net/10362/146961
dc.identifier.urlhttps://www.scopus.com/pages/publications/85069871346
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAntioxidant
dc.subjectDiospyros kaki
dc.subjectEncapsulation efficiency
dc.subjectFood supplement
dc.subjectIn vivo assessment
dc.subjectPersimmon
dc.subjectPhenolic compounds
dc.subjectPhytosomes
dc.subjectPharmaceutical Science
dc.titlePhytosomes with persimmon (Diospyros kaki l.) extracten
dc.title.subtitlePreparation and preliminary demonstration of in vivo tolerabilityen
dc.typejournal article
degois.publication.issue6
degois.publication.titlePharmaceutics
degois.publication.volume11
dspace.entity.typePublication
rcaap.rightsopenAccess

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