Mechano-epigenetic control of neural crest collective cell migration in vivo

Financiador

Organização

Publicações

Publication . Saraiva, Joana Estudante; Barriga, Elias

"A number of chromatin posttranslational modifications (PTMs), such as histone methylation and acetylation, are involved in the initiation of collective cell migration (CCM) in neural crest cells and other cell types1-3. These PTMs function primarily to fine-tune the chromatin landscape to allow for appropriate patterns of gene expression that control cell fate decisions and plasticity4-7. However, how cells dynamically fine-tune transcriptional programs to adapt their behavior in response to environmental cues remains elusive. One such mark, histone H3 lysine (K) 4 trimethylation (H3K4me3), has been demonstrated to enable neural crest CCM8 and plays critical roles in reinforcing permissive gene expression. In addition, the onset of neural crest CCM is mechanically controlled by stiffening of the tissue that they use as a migratory substrate, the mesoderm (...)."

2025-11-27Tese de doutoramento

Acesso embargado

Ver mais

Entidade financiadora

Fundação para a Ciência e a Tecnologia

Número da atribuição

UI/BD/152251/2021