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Projeto de investigação
Development of PORphyrin-triPhenylPosphonium PhotoSensitizers for Photodynamic Inactivation of microorganisms
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Ruthenium and iridium complexes bearing porphyrin moieties
Publication . Moura, Nuno M. M.; Castro, Kelly A. D. F.; Biazzotto, Juliana C.; Prandini, Juliana A.; Lodeiro, Carlos; Faustino, Maria A. F.; Simões, Mário M. Q.; da Silva, Roberto S.; Neves, Maria G. P. M. S.; LAQV@REQUIMTE; Elsevier
Porphyrin derivatives present an excellent ability to act as photosensitizers (PS) in photodynamic therapy (PDT). Ruthenium and iridium complexes, mainly containing pyridine ligands, also have been highlighted as potential PS for PDT, due to their photochemical and photophysical properties. The combination of porphyrin derivatives with iridium or ruthenium ions may create singular features and, consequently, improve the PDT effect. In this paper, we report the synthesis, characterization and efficacy of porphyrin derivatives bearing attached ruthenium or iridium terpyridine units to act as PS against resistant melanoma cells (B16F10 cell model). The choice of the porphyrin derivatives to carry out this study was related with their efficacy to generate reactive oxygen species (ROS), the presence of anchoring groups to enable the coordination with ruthenium and iridium metal ions and on the studies of subcellular localization. In the PDT studies, a cell viability decrease was observed in the presence of compounds 4a (ruthenium derivative) and 3b (iridium derivative) at lower concentrations due to the high values of singlet oxygen quantum yield and cellular uptake found. The fluorescence of derivative 3b was observed uniformly dispersed by the cells.
New Bis-Cyclometalated Iridium(III) Complexes with β-Substituted Porphyrin-Arylbipyridine as the Ancillary Ligand
Publication . Moura, Nuno M. M.; Serra, Vanda Vaz; Bastos, Alexandre; Biazotto, Juliana C.; Castro, Kelly A. D. F.; Faustino, Maria Amparo F.; Lodeiro, Carlos; da Silva, Roberto S.; Neves, Maria da Graça P. M. S.; DQ - Departamento de Química; LAQV@REQUIMTE; MDPI - Multidisciplinary Digital Publishing Institute
An efficient synthetic access to new cationic porphyrin-bipyridine iridium(III) bis-cyclometalated complexes was developed. These porphyrins bearing arylbipyridine moieties at β-pyrrolic positions coordinated with iridium(III), and the corresponding Zn(II) porphyrin complexes were spectroscopically, electrochemically, and electronically characterized. The features displayed by the new cyclometalated porphyrin-bipyridine iridium(III) complexes, namely photoinduced electron transfer process (PET), and a remarkable efficiency to generate 1O2, allowing us to envisage new challenges and opportunities for their applications in several fields, such as photo(catalysis) and photodynamic therapies.
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Entidade financiadora
Fundação para a Ciência e a Tecnologia
Programa de financiamento
3599-PPCDT
Número da atribuição
EXPL/QUI-QOR/0586/2021