WHO, WHEN AND HOW: DISSECTING THE AMYGDALA-MEDIAL PREFRONTAL CORTEX INTERPLAY DURING TRACE FEAR CONDITIONING

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Multiplexed simultaneous representations of cognitive and motor features, in the mouse medial prefrontal cortex, during a memory guided behavior

Publication . Afonso, João; Renart, Alfonso

"When using behavioral paradigms to investigate the neural basis of certain behaviors, or cognitive processes, one must first make sure to completely understand how the subjects are solving them. Delayed response tasks have been successfully used in investigating WM at the behavioral and neural level, but, given their design, with the cue immediately giving away the future response, subjects have been found to use behavioral strategies to avoid the need of keeping a memory during their cue absent period. Here we present an head-fixed delayed response task on a treadmill, for mice, that allows us to precisely monitor the behavior of the animals while simultaneously performing multi-electrode acute recordings.(...)"

2019-02-14Tese de doutoramento

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Entidade financiadora

Fundação para a Ciência e a Tecnologia

Programa de financiamento

OE

Número da atribuição

SFRH/BD/51898/2012