Developing Tools to understand DNA Damage

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Metal Complexes Stabilized by Nucleobases and Their Analogues: Synthesis and Applications

Publication . Francescato, Giulia; Petronilho, Ana

"This thesis work is structured into four main sections. The first chapter is a general introduction, initiated with a discussion of the structure and the electronic properties of N-heterocyclic carbenes (NHCs). Furthermore, it focuses on the importance of NHCs in organometallic chemistry and the use of NHCs as ligands for metal complexes with potential biological applications. The introductory chapter also contains a review of key examples of metal complexes containing nucleobases and their analogues. This synopsis explores both the synthesis and the biological application of these complexes. Finally, the aim of this thesis work is outlined: synthesize new metal complexes containing nucleobases or analogues as NHCs and study their biological applications.(...)"

2024-03-31Tese de doutoramento

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Fundação para a Ciência e a Tecnologia

Número da atribuição

SFRH/BD/144441/2019