HIPPOCAMPAL SYNAPTIC PLASTICITY INDUCED BY NATURAL SPIKE TRAINS

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Activity dynamics lead to diverse structural plasticity at single dendritic spines

Publication . Argunsah, Ali Ozgur; Israely, Inbal

Synapses are the sites at which learning is proposed to occur through changes in the strength of neuronal connections. Utilizing 2-photon mediated glutamate uncaging and imaging, the size of a dendritic spine and the amount of current which that synapse conducts has been shown to be linearly correlated and thus allows for structural changes in spine volumes to serve as a proxy for measuring plasticity. In order to e ciently and accurately quantify such structural dynamics, we developed a Matlab-based toolbox, named SpineS, which automatically analyses dendritic spine volume changes more rapidly, and with greater precision, based on a learned library of representative images. Regularly spaced stimulations, such as the high- and low-frequency patterns traditionally used to induce plasticity in the hippocampus, are not the most common forms of activity which occur in the brain.(...)

2016Tese de doutoramento

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Entidade financiadora

Fundação para a Ciência e a Tecnologia

Número da atribuição

SFRH/BD/51264/2010