Chemical composition of medicinal plants from Angola

Financiador

Organização

Publicações

Three New Labdanes Isolated from Eragrostis viscosa

Publication . Gaspar, Jorge F.; Martins, Célia; Rueff, José; Rueff, Jose; NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM); Sociedade Brasileira de Quimica / Sociedade Brasileira de Qu�mica, SBQ

Three new labdanes with 8 alpha,15-epoxy ring {[}methyl 8 alpha,15-epoxylabdan-16 beta-oate, 8 alpha,15-epoxylabdan-16 beta-ol and 8 alpha,15-epoxy-16-norlabdan-13 beta-ol] and five known compounds {[}8 alpha,15-epoxy-16-norlabdan-13-one, 8 alpha,15-epoxylabdan-16 beta-oic acid, 3 beta-(3 `',4 `'-dihydroxy)-(E)-cinnamoyloxylup-20(29)-ene, 3-(2',3' 4',6'-tetra-O-acetyl-beta-D-glucopyranosyloxy)-beta-sitosterol and 16-acetoxy-8 alpha,15-epoxylabdane] were isolated from toluene and dichloromethane extracts of aerial parts of Eragrostis viscosa. The structures of all the compounds were established based on their spectroscopic data and X-ray diffraction analysis of 8 alpha,15-epoxylabdan-16 beta-ol. It was also studied the genotoxicity of E. viscosa, particularly compounds 16-acetoxy-8 alpha,15-epoxylabdane, 8 alpha,15-epoxy-16-norlabdan-13-one and 8 alpha,15-epoxilabdan-16 beta-ol, using a cytokinesis-block micronucleus assay and the Ames test to assess mutagenicity. Both assays were negative. Cytotoxicity was also analyzed using an MTT assay, and 8 alpha,15-epoxy-16 beta-ol was shown to be the most cytotoxic of the compounds tested. E. viscosa extracts were also tested to determine their antioxidant capacities, peroxide values and total phenolic contents.}}

2012-10Artigo científico

Acesso aberto

Ver mais

Entidade financiadora

Fundação para a Ciência e a Tecnologia

Programa de financiamento

POCI

Número da atribuição

POCTI/QUI/39380/2001