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Projeto de investigação
IONGELS: FROM NEW CHEMISTRY TOWARD EMERGING APPLICATIONS
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Publicações
Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties
Publication . Luque, Gisela C.; Moya, Melissa; Picchio, Matias L.; Bagnarello, Vanessa; Valerio, Idalia; Bolaños, José; Vethencourt, María; Gamboa, Sue Hellen; Tomé, Liliana C.; Minari, Roque J.; Mecerreyes, David; LAQV@REQUIMTE; DQ - Departamento de Química; MDPI - Multidisciplinary Digital Publishing Institute
There is an actual need for developing materials for wound healing applications with anti-inflammatory, antioxidant, or antibacterial properties in order to improve the healing performance. In this work, we report the preparation and characterization of soft and bioactive iongel materials for patches, based on polymeric poly(vinyl alcohol) (PVA) and four ionic liquids containing the cholinium cation and different phenolic acid anions, namely cholinium salicylate ([Ch][Sal]), cholinium gallate ([Ch][Ga]), cholinium vanillate ([Ch][Van]), and cholinium caffeate ([Ch][Caff]). Within the iongels, the phenolic motif in the ionic liquids plays a dual role, acting as a PVA crosslinker and a bioactive compound. The obtained iongels are flexible, elastic, ionic conducting, and thermoreversible materials. Moreover, the iongels demonstrated high biocompatibility, non-hemolytic activity, and non-agglutination in mice blood, which are key-sought material specifications in wound healing applications. All the iongels have shown antibacterial properties, being PVA-[Ch][Sal], the one with higher inhibition halo for Escherichia Coli. The iongels also revealed high values of antioxidant activity due to the presence of the polyphenol, with the PVA-[Ch][Van] iongel having the highest activity. Finally, the iongels show a decrease in NO production in LPS-stimulated macrophages, with the PVA-[Ch][Sal] iongel displaying the best anti-inflammatory activity (>63% at 200 µg/mL).
Conducting Polymer-Ionic Liquid Electrode Arrays for High-Density Surface Electromyography
Publication . Velasco-Bosom, Santiago; Karam, Nuzli; Carnicer-Lombarte, Alejandro; Gurke, Johannes; Casado, Nerea; Tomé, Liliana C.; Mecerreyes, David; Malliaras, George G.; LAQV@REQUIMTE; DQ - Departamento de Química; John Wiley and Sons Inc.
Surface electromyography (EMG) is used as a medical diagnostic and to control prosthetic limbs. Electrode arrays that provide large-area, high density recordings have the potential to yield significant improvements in both fronts, but the need remains largely unfulfilled. Here, digital fabrication techniques are used to make scalable electrode arrays that capture EMG signals with mm spatial resolution. Using electrodes made of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) composites with the biocompatible ionic liquid (IL) cholinium lactate, the arrays enable high quality spatiotemporal recordings from the forearm of volunteers. These recordings allow to identify the motions of the index, little, and middle fingers, and to directly visualize the propagation of polarization/depolarization waves in the underlying muscles. This work paves the way for scalable fabrication of cutaneous electrophysiology arrays for personalized medicine and highly articulate prostheses.
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Entidade financiadora
European Commission
Programa de financiamento
H2020
Número da atribuição
823989