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Ocean bioprospecting: targeting marine actinomycetes as a source for lead-like drug discovery
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Metabolomic fingerprinting of salinispora From Atlantic Oceanic Islands
Publication . Bauermeister, Anelize; Velasco-Alzate, Karen; Dias, Tiago; Macedo, Helena; Ferreira, Elthon G.; Jimenez, Paula C.; Lotufo, Tito M.C.; Lopes, Norberto P.; Gaudêncio, Susana P.; Costa-Lotufo, Letícia V.; UCIBIO - Applied Molecular Biosciences Unit; DQ - Departamento de Química; DCV - Departamento de Ciências da Vida; Frontiers Research Foundation
Salinispora (Micromonosporaceae) is an obligate marine bacterium genus consisting of three species that share over 99% 16S rRNA identity. The genome and biosynthetic pathways of the members of this genus have been widely investigated due to their production of species-specific metabolites. However, despite the species' high genetic similarity, site-specific secondary metabolic gene clusters have been found in Salinispora strains collected at different locations. Therefore, exploring the metabolic expression of Salinispora recovered from different sites may furnish insights into their environmental adaptation or their chemical communication and, further, may lead to the discovery of new natural products. We describe the first occurrence of Salinispora strains in sediments from the Saint Peter and Saint Paul Archipelago (a collection of islets in Brazil) in the Atlantic Ocean, and we investigate the metabolic profiles of these strains by employing mass-spectrometry-based metabolomic approaches, including molecular networking from the Global Natural Products Social Molecular Networking platform. Furthermore, we analyze data from Salinispora strains recovered from sediments from the Madeira Archipelago (Portugal, Macaronesia) in order to provide a wider metabolomic investigation of Salinispora strains from the Atlantic Oceanic islands. Overall, our study evidences a broader geographic influence on the secondary metabolism of Salinispora than was previously proposed. Still, some biosynthetic gene clusters, such as those corresponding to typical chemical signatures of S. arenicola, like saliniketals and rifamycins, are highly conserved among the assessed strains.
A New Network for the Advancement of Marine Biotechnology in Europe and Beyond
Publication . Ocean4Biotech; Gaudêncio, Susana P.; UCIBIO - Applied Molecular Biosciences Unit; DQ - Departamento de Química; Frontiers Media
Marine organisms produce a vast diversity of metabolites with biological activities useful for humans, e.g., cytotoxic, antioxidant, anti-microbial, insecticidal, herbicidal, anticancer, pro-osteogenic and pro-regenerative, analgesic, anti-inflammatory, anti-coagulant, cholesterol-lowering, nutritional, photoprotective, horticultural or other beneficial properties. These metabolites could help satisfy the increasing demand for alternative sources of nutraceuticals, pharmaceuticals, cosmeceuticals, food, feed, and novel bio-based products. In addition, marine biomass itself can serve as the source material for the production of various bulk commodities (e.g., biofuels, bioplastics, biomaterials). The sustainable exploitation of marine bio-resources and the development of biomolecules and polymers are also known as the growing field of marine biotechnology. Up to now, over 35,000 natural products have been characterized from marine organisms, but many more are yet to be uncovered, as the vast diversity of biota in the marine systems remains largely unexplored. Since marine biotechnology is still in its infancy, there is a need to create effective, operational, inclusive, sustainable, transnational and transdisciplinary networks with a serious and ambitious commitment for knowledge transfer, training provision, dissemination of best practices and identification of the emerging technological trends through science communication activities. A collaborative (net)work is today compelling to provide innovative solutions and products that can be commercialized to contribute to the circular bioeconomy. This perspective article highlights the importance of establishing such collaborative frameworks using the example of Ocean4Biotech, an Action within the European Cooperation in Science and Technology (COST) that connects all and any stakeholders with an interest in marine biotechnology in Europe and beyond.
XVI International Symposium on Marine Natural Products|XI European Conference on Marine Natural Products
Publication . Pedrosa, Rui; Gaudêncio, Susana P.; Vasconcelos, Vitor; UCIBIO - Applied Molecular Biosciences Unit; DQ - Departamento de Química; MDPI - Multidisciplinary Digital Publishing Institute
The International Symposium on Marine Natural Products (MaNaPro) happened for the first time in 1975 in the city of Aberdeen, Scotland, organized by Professor Ronald H [...].
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IF/00700/2014/CP1224/CT0007