Effect of radio- and chemotherapy on cancer cell invasion: the role of macrophages

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Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours

Publication . Ferreira, José Alexandre; Videira, Paula A.; Lima, Luís; Pereira, Sofia; Silva, Mariana; Carrascal, Mylene; Severino, Paulo F.; Fernandes, Elisabete; Almeida, Andreia; Costa, Céu; Vitorino, Rui; Amaro, Teresina; Oliveira, Maria J.; Reis, Celso A.; Dall'Olio, Fabio; Amado, Francisco; Santos, Lúcio Lara; NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM); Centro de Estudos de Doenças Crónicas (CEDOC); Wiley

Little is known on the expression of the tumour-associated carbohydrate antigen sialyl-Tn (STn), in bladder cancer. We report here that 75% of the high-grade bladder tumours, presenting elevated proliferation rates and high risk of recurrence/progression expressed STn. However, it was mainly found in non-proliferative areas of the tumour, namely in cells invading the basal and muscle layers. STn was also found in tumour-adjacent mucosa, which suggests its dependence on a field effect of the tumour. Furthermore, it was not expressed by the normal urothelium, demonstrating the cancer-specific nature of this antigen. STn expression correlated with that of sialyltransferase ST6GalNAc. I, its major biosynthetic enzyme. The stable expression of ST6GalNAc. I in the bladder cancer cell line MCR induced STn expression and a concomitant increase of cell motility and invasive capability. Altogether, these results indicate for the first time a link between STn expression and malignancy in bladder cancer. Hence, therapies targeting STn may constitute new treatment approaches for these tumours.

2013-06Artigo científico

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Fundação para a Ciência e a Tecnologia

Programa de financiamento

5876-PPCDTI

Número da atribuição

PTDC/SAU-ONC/112511/2009