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Challenges in matrix metalloproteinases inhibition
Publication . Laronha, Helena; Carpinteiro, Inês; Portugal, Jaime; Azul, Ana Cristina; Polido, Mário; Petrova, Krasimira T.; Salema-Oom, Madalena; Caldeira, Jorge; LAQV@REQUIMTE; UCIBIO - Applied Molecular Biosciences Unit; MDPI - Multidisciplinary Digital Publishing Institute
Matrix metalloproteinases are enzymes that degrade the extracellular matrix. They have different substrates but similar structural organization. Matrix metalloproteinases are involved in many physiological and pathological processes and there is a need to develop inhibitors for these enzymes in order to modulate the degradation of the extracellular matrix (ECM). There exist two classes of inhibitors: endogenous and synthetics. The development of synthetic inhibitors remains a great challenge due to the low selectivity and specificity, side effects in clinical trials, and instability. An extensive review of currently reported synthetic inhibitors and description of their properties is presented.
Structure and Function of Human Matrix Metalloproteinases
Publication . Laronha, Helena; Caldeira, Jorge; UCIBIO - Applied Molecular Biosciences Unit; LAQV@REQUIMTE; MDPI - Multidisciplinary Digital Publishing Institute
The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenance of collagen, and consequently of ECM, is involved in several biological processes and it must be strictly regulated by endogenous inhibitors (TIMPs). The deregulation of MMPs activity leads to development of numerous diseases. This review shows MMPs complexity.
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Fundação para a Ciência e a Tecnologia
Programa de financiamento
3599-PPCDT
Número da atribuição
PTDC/SAU-BMA/122444/2010