Waste Elimination using Ionic Liquid Bio-Engineered Eukariotic Organisms

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Triggering secondary metabolite biosynthesis: exploring the effects of ionic liquids in fungal metabolism

Publication . Alves, Paula Cristina; Pereira, Cristina Silva; Becker, Jörg

Filamentous fungi are able to synthesise an array of small molecules (secondary metabolites), which are usually not essential for fungal growth but confer competitiveness. As a consequence, numerous secondary metabolites remain cryptic at the artificial conditions of cultivation in a research laboratory. Even in Aspergillus nidulans, one of the most well studied fungi, numerous metabolites remain unseen. Several strategies have been used to solve this knowledge gap, some of which require prior knowledge of genomic sequences, relying on manipulation of targeted genes encoding components of either secondary metabolism or regulatory pathways. Other approaches may be applied also in less well characterised strains, such as cultivation with other species/organisms or modification of the growth media composition. (...)

2016-04Tese de doutoramento

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Entidade financiadora

Fundação para a Ciência e a Tecnologia

Programa de financiamento

3599-PPCDT

Número da atribuição

PTDC/QUI/71331/2006