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Consequences of centriole aberrations in cancer

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Understanding PLK4’s role in cancer
Publication . Martins Leal Fonseca, Irina Suheila; Bettencourt-Dias, Mónica
Centrioles are essential organelles within eukaryotic cells, as centrosomes forming the main microtubule organizing center of cycling animal cells, and also as basal bodies templating cilia and flagella assembly. Due to their essential functions in cells, centriole biogenesis is tightly regulated in space, time and number. However, several diseases have been associated to deregulation of those structures, including cancer.

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Fundação para a Ciência e a Tecnologia

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SFRH/BD/128394/2017

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