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Projeto de investigação
Next generation of bioconductive soft materials: can biobased iongels be a solution?
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Publicações
Overview of Membrane Science and Technology in Portugal
Publication . Tomé, Liliana C.; Santos, Diogo M. F.; Velizarov, Svetlozar; Coelhoso, Isabel M.; Mendes, Adélio; Crespo, João G.; de Pinho, Maria Norberta; LAQV@REQUIMTE; DQ - Departamento de Química; MDPI AG
Membrane research in Portugal is aligned with global concerns and expectations for sustainable social development, thus progressively focusing on the use of natural resources and renewable energy. This review begins by addressing the pioneer work on membrane science and technology in Portugal by the research groups of Instituto Superior Técnico—Universidade de Lisboa (IST), NOVA School of Science and Technology—Universidade Nova de Lisboa (FCT NOVA) and Faculdade de Engenharia—Universidade do Porto (FEUP) aiming to provide an historical perspective on the topic. Then, an overview of the trends and challenges in membrane processes and materials, mostly in the last five years, involving Portuguese researchers, is presented as a contribution to a more sustainable water–energy–material–food nexus.
Polyphenol Iongel Patches with Antimicrobial, Antioxidant and Anti-Inflammatory Properties
Publication . Luque, Gisela C.; Moya, Melissa; Picchio, Matias L.; Bagnarello, Vanessa; Valerio, Idalia; Bolaños, José; Vethencourt, María; Gamboa, Sue Hellen; Tomé, Liliana C.; Minari, Roque J.; Mecerreyes, David; LAQV@REQUIMTE; DQ - Departamento de Química; MDPI - Multidisciplinary Digital Publishing Institute
There is an actual need for developing materials for wound healing applications with anti-inflammatory, antioxidant, or antibacterial properties in order to improve the healing performance. In this work, we report the preparation and characterization of soft and bioactive iongel materials for patches, based on polymeric poly(vinyl alcohol) (PVA) and four ionic liquids containing the cholinium cation and different phenolic acid anions, namely cholinium salicylate ([Ch][Sal]), cholinium gallate ([Ch][Ga]), cholinium vanillate ([Ch][Van]), and cholinium caffeate ([Ch][Caff]). Within the iongels, the phenolic motif in the ionic liquids plays a dual role, acting as a PVA crosslinker and a bioactive compound. The obtained iongels are flexible, elastic, ionic conducting, and thermoreversible materials. Moreover, the iongels demonstrated high biocompatibility, non-hemolytic activity, and non-agglutination in mice blood, which are key-sought material specifications in wound healing applications. All the iongels have shown antibacterial properties, being PVA-[Ch][Sal], the one with higher inhibition halo for Escherichia Coli. The iongels also revealed high values of antioxidant activity due to the presence of the polyphenol, with the PVA-[Ch][Van] iongel having the highest activity. Finally, the iongels show a decrease in NO production in LPS-stimulated macrophages, with the PVA-[Ch][Sal] iongel displaying the best anti-inflammatory activity (>63% at 200 µg/mL).
Poly(Ethylene glycol) diacrylate iongel membranes reinforced with nanoclays for co2 separation
Publication . Nabais, Ana R.; Francisco, Rute O.; Alves, Vítor D.; Neves, Luísa A.; Tomé, Liliana C.; LAQV@REQUIMTE; DQ - Departamento de Química; MDPI AG
Despite the fact that iongels are very attractive materials for gas separation membranes, they often show mechanical stability issues mainly due to the high ionic liquid (IL) content (≥60 wt%) needed to achieve high gas separation performances. This work investigates a strategy to improve the mechanical properties of iongel membranes, which consists in the incorporation of montmorillonite (MMT) nanoclay, from 0.2 to 7.5 wt%, into a cross-linked poly(ethylene glycol) diacrylate (PEGDA) network containing 60 wt% of the IL 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([C2mim][TFSI]). The iongels were prepared by a simple one-pot method using ultraviolet (UV) initiated polymerization of poly(ethylene glycol) diacrylate (PEGDA) and characterized by several techniques to assess their physico-chemical properties. The thermal stability of the iongels was influenced by the addition of higher MMT contents (>5 wt%). It was possible to improve both puncture strength and elongation at break with MMT contents up to 1 wt%. Furthermore, the highest ideal gas selectivities were achieved for iongels containing 0.5 wt% MMT, while the highest CO2 permeability was observed at 7.5 wt% MMT content, due to an increase in diffusivity. Remarkably, this strategy allowed for the preparation and gas permeation of self-standing iongel containing 80 wt% IL, which had not been possible up until now.
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Entidade financiadora
Fundação para a Ciência e a Tecnologia
Programa de financiamento
CEEC IND 3ed
Número da atribuição
2020.01555.CEECIND/CP1586/CT0034