iNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG and ITQB)

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Metabolic Systems Biology for Stem Cell Bioprocesses

Publication . Sá, João Alberto Pacheco Marques de Vasconcelos; Carrondo, Manuel; Isidro, Inês

"The application of stem cell-derived products for human health is in its infancy. Different applications of stem cell bioprocesses – cell therapy, discovery of new targets for regenerative medicine, disease modeling, drug and toxicity testing – have common hurdles. The most relevant hurdle is the lack of quality of cell products due to inefficient and ineffective stem cell differentiation procedures. Differentiated cells in vitro do not behave similarly to mature cells in vivo despite presenting similar surface and intracellular protein biomarkers. Our current weak understanding of cell “behavior” contributes to lack of cell functionality of produced cells and make these inadequate for cell therapy, disease modeling, drug screening and toxicity. Cells communicate with the environment and with neighboring cells, usually through secreted factors and through metabolites. This communication is guaranteed by an adjustable and controlled internal system in which metabolism is very important. (...)"

2020-04-21Tese de doutoramento

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Entidade financiadora

Fundação para a Ciência e a Tecnologia

Programa de financiamento

6817 - DCRRNI ID

Número da atribuição

UID/Multi/04462/2019