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Projeto de investigação
Development of novel multifunctional nano-polyplexes as imaging and delivery vectors against triple negative breast cancer
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Synthesis, Characterization and Applications of Gold and Silver Nanoparticles: From Antibacterial to Optoelectronic Nanomaterials
Publication . Djafari, Jamila; Capelo Martinez, José; Lodeiro Espiño, Carlos; Fernandez-Lodeiro, Javier
The Research and development of new metallic nanoparticles (NPs) have been booming in recent decades as a result of the advantageous properties presented by these nanomaterials. Their metallic nature associated with their tiny size induce physicochemical properties that constitute a real advantage for the construction of a new range of nano-metric materials with potential applications in biomedical, electronic, optical or catalytic fields, among many others. Until now, many scientific and technological fields are obtaining great benefits by the utilization and development of gold and silver nanomaterials. However currently, it is necessary to develop new reproducible methodologies allowing a greater understanding of the nano-scale materials thus promoting the construction of most precise and more complex gold and silver NPs through the control of their size, shape and composition, allowing new reviewed applications.
With the aim to introduce new synthetic advances in the nanotechnology area, in the present doctoral thesis we have studied: i) The synthesis and characterization of bio-functionalized gold NPs with proteins; ii) The development of a nobel synthetic approach to produce gold and silver NPs using Tetracycline as synthetic agent; iii) The synthesis and functionalization of silver triangular nanoplates and their subsequent controlled organic and inorganic (silica layer) coating; and iv) the creation of a novelty synthesis of pseudo-spherical, multi-tip or raspberry like AuNPs using Iron (II) as Green reducing agent.
Furthermore, the antimicrobial and optoelectronic properties of the produced NPs and their applications have been explored and studied.
Synthesis of mesoporous silica coated gold nanorods loaded with methylene blue and its potentials in antibacterial applications
Publication . Fernández-Lodeiro, Adrián; Djafari, Jamila; Fernández-Lodeiro, Javier; Duarte, Maria Paula; Mauricio, Elisabete Muchagato; Capelo-Martínez, José Luis; Lodeiro, Carlos; LAQV@REQUIMTE; DQ - Departamento de Química; MEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de Recursos; DCTB - Departamento de Ciências e Tecnologia da Biomassa (ex-GDEH); MDPI AG
In this work, the successful preparation and characterization of gold nanorods (AuNRs) coated with a mesoporous silica shell (AuNRs@Simes) was achieved. Conjugation with methylene blue (MB) as a model drug using ultrasound-stimulated loading has been explored for further application in light-mediated antibacterial studies. Lyophilization of this conjugated nanosystem was analyzed using trehalose (TRH) as a cryogenic protector. The obtained stable dry formulation shows potent antimicrobial activity against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria after a simple post-treatment irradiation method with a red laser during a short time period.
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Entidade financiadora
Fundação para a Ciência e a Tecnologia
Programa de financiamento
3599-PPCDT
Número da atribuição
PTDC/QEQ-MED/2118/2014