A carregar...
Projeto de investigação
Novel Chemical Stratefies for early detection of neurodegenerative diseases
Financiador
Autores
Publicações
Novel Strategies for early detection of Neurodegenerative Diseases
Publication . Forte, Andreia; Marrucho, Isabel; Branco, Luís
"Neurodegenerative diseases are incurable and highly incapacitating diseases characterized by the progressive degeneration and death of neural tissues. According to World Health Organization, it is estimated that almost 50 million people have dementia worldwide and it is expected that this number triple by 2050. One of the main problems associated with this type of pathologies, is the late stage of detection implying a less effective treatment options. In this context, Magnetic resonance imaging (MRI) has gained greater attention in the most recent years. Several studies have been carried out to find new molecules with the ability to increase the contrast between tissues allowing a more accurate and early diagnosis of these diseases. Also, new molecules have been designed over the years to find new compounds that could elucidate β-amyloid aggregation through luminescent methodologies.(...)"
Lanthanide-Based Organic Salts
Publication . Forte, Andreia; Gago, Sandra; Alves, Celso; Silva, Joana; Alves, Joana; Pedrosa, Rui; Laia, César A. T.; Marrucho, Isabel M.; Branco, Luís C.; Instituto de Tecnologia Química e Biológica António Xavier (ITQB); LAQV@REQUIMTE; MDPI - Multidisciplinary Digital Publishing Institute
The formulation of magnetic ionic liquids (MILs) or organic salts based on lanthanides as anions has been explored. In this work, a set of choline-family-based salts, and two other, different cation families, were combined with Gadolinium(III) and Terbium(III) anions. Synthetic methodologies were previously optimized, and all organic salts were obtained as solids with melting temperatures higher than 100 °C. The magnetic moments obtained for the Gd(III) salts were, as expected, smaller than those obtained for the Tb(III)-based compounds. The values for Gd(III) and Tb(III) magnetic salts are in the range of 6.55–7.30 MB and 8.22–9.34 MB, respectively. It is important to note a correlation between the magnetic moments obtained for lanthanides, and the structural features of the cation. The cytotoxicity of lanthanide-based salts was also evaluated using 3T3, 293T, Caco2, and HepG2 cells, and it was revealed that most of the prepared compounds are not toxic.
Unidades organizacionais
Descrição
Palavras-chave
Contribuidores
Financiadores
Entidade financiadora
Fundação para a Ciência e a Tecnologia
Programa de financiamento
OE
Número da atribuição
PD/BD/109625/2015