Transposable element awakening: How environmental change produces genetic variation.

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Effects of Wolbachia on transposable element dynamics and on fitness traits in Drosophila melanogaster

Publication . Eugénio, Ana; Beldade, Patrícia

Transposable elements (TEs) are repeƟƟve DNA sequences capable of changing posiƟon independently of their host genome, and that are widespread across eukaryotes (Bourque et al. 2018; Wells & Feschotte 2020). TE mobilization can produce genetic variation, which may affect host adaptation and resistance to environmental change (Pappalardo et al. 2021; Liu et al. 2022) and produce novel gene or gene regulatory networks (Trizzino et al. 2017). Furthermore, TEs have potenƟal applicaƟons in biotechnology (Sandoval-Villegas et al. 2021) and in gene therapy (Amberger & Ivics 2020). However, TE mobilizaƟon can also be disrupƟve and generate deleterious mutaƟons that cause disabiliƟes and diseases (Ni et al. 2017; Payer & Burns 2019). Because of the many effects of TEs on genome evoluƟon and funcƟon, and on host biology, as well as their potenƟal contribuƟon to novel therapeuƟc strategies and their role in disease, it is crucially important to study TEs and their behaviour, and the factors that affect them.

2023-12-11Tese de doutoramento

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Fundação para a Ciência e a Tecnologia

Número da atribuição

SFRH/BD/115535/2016