Comparison of the functional organization across different cortical fedback inputs to primary visual cortex

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Functional organization of cortico-cortical feedback originating from different laminar sources and how it is shaped by experience

Publication . Rajan, Radhika; Petreanu, Leopoldo

"Contextual modulations play a critical role in shaping visual perception. Cortical feedback (FB) projections are thought to underlie these modulations, but a comprehensive understanding requires knowledge of the organizational principles governing different FB pathways. We used wild-type as well as transgenic mouse lines and simultaneous dual-color two-photon recordings of axons and somata to measure the functional organization of cortico-cortical FB originating from different laminae of the lateromedial (LM) visual area in primary visual cortex (V1). Our findings reveal that although FB inputs from both layer (L) 2/3 and L5 predominantly project to L1 of V1, they exhibit different innervation profiles in V1. Irrespective of visual experience and laminar origin, FB inputs, on average, are retinotopically matched in V1. However, L5 FB inputs conveyed information from more distal surround locations to V1 compared to those from L2/3, regardless of visual experience. The FB projections exhibit spatiotemporal tuning-dependent retinotopic biases that were influenced by visual experience.(...)"

2023-12-04Tese de doutoramento

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Entidade financiadora

Fundação para a Ciência e a Tecnologia

Programa de financiamento

OE

Número da atribuição

PD/BD/128306/2017