PROGRAMA DOUTORAL EM BIOLOGIA INTEGRATIVA E BIOMEDICINA IBB 2014

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Cohesion failure and Mitosis: From Molecular Mechanisms to Organismal Consequences

Publication . Mirkovic, Mihailo; Oliveira, Raquel

"Mitosis is a dynamic culmination of the cell cycle, resulting in generation of two daughter cells from one mother. In order for this to happen, the cell must package its DNA into chromosomes and divide it equally amongst progeny. To ensure this process happens accurately, the cell glues identical chromosomes together so it can segregate them in symmetrical fashion during anaphase. The glue holding chromosomes together is a molecule called cohesin, which encompasses replicated DNA fibers via topological entrapment. The aim of this thesis was to study the immediate mitotic response to premature cohesion loss, as well as the long term consequences of such perturbed mitosis for the cell and the whole organism.(...)"

2018-07-12Tese de doutoramento

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Entidade financiadora

Fundação para a Ciência e a Tecnologia

Número da atribuição

PD/BD/52438/2013