PROGRAMA DOUTORAL EM BIOLOGIA INTEGRATIVA E BIOMEDICINA IBB 2015

Financiador

Organização

Publicações

The role of the gut microbiota in the subsistence of antibiotic resistance

Publication . Leónidas Cardoso, Luís; Gordo, Isabel

"Antibiotic resistance is one of the major contemporary threats to global health. Studies on evolutionary biology, molecular biology and genetics have revealed that many phenomena contribute for the subsistence of resistant bacteria. The environment has been shown to be a key factor, capable of altering fitness costs and the epistasis patterns between resistance determinants. Still, few studies have ventured to assess the costs of antibiotic resistance in natural environments, and such studies are centered on pathogens. It is now known that commensal bacteria can act as reservoirs of resistance, and that resistant commensals can evolve to express pathogenicity and share resistance genes with pathogens. Here, we explore how selection acts on resistant, commensal E. coli in the mouse gut. (...)"

2020-03-06Tese de doutoramento

Acesso aberto

Ver mais

Entidade financiadora

Fundação para a Ciência e a Tecnologia

Número da atribuição

PD/BD/106003/2014