Mechanisms of cardioprotection by Berries Driven Polyphenols

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Disclosing the mechanisms underlying the beneficial effects of berries-driven polyphenols: In in vitro, as well as in vivo cardiovascular models

Publication . Gomes, Andreia; Nunes dos Santos, Cláudia; Brenner, Catherine

"Nowadays, cardiovascular diseases (CVD) constitute a major health problem accounting for about 30% of deaths worldwide. Diet, one of the most important lifestyle risk factors, can strongly influence CVD progression and might afford a promising prophylaxis. Epidemiological studies have shown a consistent beneficial relationship between the consumption of fruits and vegetables, rich sources of (poly)phenols, and a reduced risk of CVD susceptibility. Abundant dietary (poly)phenols in our diet are not necessarily able to result in the highest tissue concentrations, owing to considerable differences in bioavailability. Thus, a detailed and profound knowledge on the (poly)phenols metabolic fate and the specific bioactive (poly)phenol metabolites and their molecular targets is a key point to ensure the safe use of these active phytochemicals as a nutraceutical and or therapeutic agent in a nearest future.(...)"

2020-12Tese de doutoramento

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Entidade financiadora

Fundação para a Ciência e a Tecnologia

Programa de financiamento

3599-PPCDT

Número da atribuição

FCT-ANR/BEX-BCM/0001/2013