DNA-derived N-heterocyclic carbenes as anticancer agents

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Organometallic Nucleosides: Synthesis of Platinum and Palladium complexes bearing N- Heterocyclic carbenes based on nucleosides and their anticancer activity

Publication . Leitão, Maria Inês P. S.; Orientadora: Petronilho, Ana

" Alkylation of DNA nucleobases is a common modification of the genome that results in formation of the so-called DNA adducts. Structurally, some of these adducts are N-heterocyclic carbene precursors, whose reactivity is scarcely studied. The work reported in this thesis is devoted to the synthesis of nucleoside-based NHC complexes based on palladium and platinum and to the study of their activity as anticancer agents. "

2022-09-30Tese de doutoramento

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Entidade financiadora

Fundação para a Ciência e a Tecnologia

Número da atribuição

PD/BD/135483/2018